Acta Phys. -Chim. Sin. ›› 2014, Vol. 30 ›› Issue (7): 1354-1362.doi: 10.3866/PKU.WHXB201405121

• BIOPHYSICAL CHEMISTRY • Previous Articles     Next Articles

Syntheses, Structures, Antifungal Activities and DNACleavage of Transition Metal Coordination Compounds with 4-(1H-1,2,4-triazol-1-ylmethyl) Benzoic Acid

LI Jie1, XIONG Ping-Ping2, BU Huai-Yu1, CHEN San-Ping2   

  1. 1. Shaanxi Provincial Key Laboratory of Biotechnology, Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education, Northwest University, Xi'an 710069, P. R. China;
    2. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069, P. R. China
  • Received:2014-02-26 Revised:2014-05-12 Published:2014-06-30
  • Contact: BU Huai-Yu, CHEN San-Ping E-mail:buhy@nwu.edu.cn;sanpingchen@126.com
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (31201534, 21373162, 21203149, 21127004, 21173168).

Abstract:

Three novel transitionmetal compounds [Cu0.5L]n (1), {[Ni(L)2·(H2O)2]·(H2O)2}n(2), and {[Co(L)2·(H2O)2]· (H2O)2}n (3), were hydrothermally synthesized with 4-(1H-1,2,4-triazol-1-ylmethyl) benzoic acid (HL) and characterized by infrared spectroscopy, elemental analyses, single-crystal X-ray diffraction, thermal analyses, UV-Vis spectroscopy, and fluorescence spectroscopy. Structural analyses reveal that compound 1 features a one-dimensional (1D) chain, while isomorphic 2 and 3 exhibit a three-dimensional (3D) network structure with interchain hydrogen-bonding. Antifungal activities tests reveal that 1 has the highest antifungal effect on the five fungi (Fusarium graminearum, Vasa mali, Macrophoma kawatsukai, Colletotrichum gloeosporioides, and Alternaria alternate) among the three compounds. Furthermore, DNA cleavage experiments indicate that compound 1 has more efficient DNA (pUC 18) cleavage activity than compounds 2 and 3. The binding properties of the three compounds with DNA were also investigated by absorption. The results show that the three compounds can intercalate into DNA, and the interaction of compound 1 is the strongest.

Key words: Transition metal compound, Crystal structure, Antifungal activity, DNA cleavage activity, DNA intercalation

MSC2000: 

  • O642