Acta Phys. -Chim. Sin. ›› 2015, Vol. 31 ›› Issue (6): 1199-1206.doi: 10.3866/PKU.WHXB201504021

• PHYSICAL CHEMISTRY OF MATERIALS • Previous Articles     Next Articles

Preparation of Mg2Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexagonal Lyotropic Liquid Crystal and Their Application as Drug Carriers

ZHAO Ji-Kuan1, XIE Yan-Fang1, XU Jie1, HOU Wan-Guo2   

  1. 1 State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, Shandong Province, P. R. China;
    2 Key Laboratory of Colloid and Interface Chemistry Ministry of Education, Shandong University, Jinan 250100, P. R. China
  • Received:2015-01-19 Revised:2015-04-02 Published:2015-06-05
  • Contact: HOU Wan-Guo E-mail:wghou@sdu.edu.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (20903059, 21173135, 21403121) and Natural Science Foundation of Shandong Province, China (ZR2009BM043, ZR2013BQ013).

Abstract:

A hexagonal lyotropic liquid crystal (LLC) was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide (LDH) nanosheets (L-LDHs) were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium (DS; DS/L-LDHs) was synthesized using an ionexchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 ℃ and pH 7.2. The results were compared with those for common LDH flaky particles (S-LDHs) synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption. The results show that the L-LDH JEparticles are less thick, and have larger specific surface areas and higher DS-loading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphologycontrolled synthesis of LDHs.

Key words: Layered double hydroxide, Lyotropic liquid crystal, Triton X-100, Nanohybrid, Drug release

MSC2000: 

  • O648.1