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Acta Physico-Chimica Sinca  2018, Vol. 34 Issue (4): 348-360    DOI: 10.3866/PKU.WHXB201708311
Special Issue: Special Issue for Highly Cited Researchers
REVIEW     
Aptamer-Conjugated Nanomaterials for Specific Cancer Diagnosis and Targeted Therapy
BAI Huarong, FAN Huanhuan, ZHANG Xiaobing, CHEN Zhuo, TAN Weihong
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, P. R. China
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Abstract  

Owing to their unique optical, electronic, magnetic, and surface plasmon resonance properties, nanomaterials have attracted significant attention for potential bioanalysis and biomedical applications. Aptamers are single-stranded oligonucleotides, which are generated by a procedure termed as SELEX (Systematic Evolution of Ligands by EXponential Enrichment) and typically demonstrate high affinity and selectivity toward their target molecules. As a result of their unique characteristics, aptamers are promising recognition units that can be conjugated with nanomaterials for cancer cell imaging, diagnosis, and cancer therapy. By integrating the recognition abilities of aptamers with the properties of nanomaterials, aptamer-conjugated nanomaterials can serve as extraordinary tools for bioimaging and cancer therapy. Recently, aptamer-conjugated nanomaterials have attracted significant attention in the field of specific cancer cell targeted therapy owing to their improved efficacy and lower toxicity. In this review, we summarize the progress achieved of aptamer-conjugated nanomaterials as nanocarriers for specific cancer cell diagnosis and targeted therapy. In addition to drug delivery for cancer therapy, the various achievements of the aptamer-conjugated nanomaterials in combination with other emerging technologies to improve the efficiency and selectivity of cancer therapy have also been reviewed.



Key wordsAptamer      Nanomaterial      Specific recognition      Cancer diagnosis      Targeted therapy     
Received: 10 July 2017      Published: 31 August 2017
MSC2000:  O644  
Fund:  

The project was supported by the National Natural Science Foundation of China (21221003, 21327009).

Corresponding Authors: TAN Weihong     E-mail: tan@chem.ufl.edu
Cite this article:

BAI Huarong, FAN Huanhuan, ZHANG Xiaobing, CHEN Zhuo, TAN Weihong. Aptamer-Conjugated Nanomaterials for Specific Cancer Diagnosis and Targeted Therapy. Acta Physico-Chimica Sinca, 2018, 34(4): 348-360.

URL:

http://www.whxb.pku.edu.cn/10.3866/PKU.WHXB201708311     OR     http://www.whxb.pku.edu.cn/Y2018/V34/I4/348

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