Acta Phys. -Chim. Sin. ›› 2017, Vol. 33 ›› Issue (4): 656-660.doi: 10.3866/PKU.WHXB201701162

• COMMUNICATION • Previous Articles     Next Articles

Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes

Kang YUAN,Xue ZHOU,Jian-Zhong DU*()   

  1. 1 Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China
    2 Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China
  • Received:2016-12-12 Published:2017-03-23
  • Contact: Jian-Zhong DU
  • Supported by:
    the National Natural Science Foundation of China(21374080);the National Natural Science Foundation of China(21674081);the National Natural Science Foundation of China(21611130175);Shanghai International Scientific Collaboration Fund, China(15230724500);Shanghai 1000 Talents Plan, and Fundamental Research Funds for the Central Universities, China(0500219211);Shanghai 1000 Talents Plan, and Fundamental Research Funds for the Central Universities, China(1500219107)


It is an important challenge to balance the degradability and stability of polymer vesicles. We report a thermo-responsive vesicle based on poly[(N-isopropyl acrylamide-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] [P (NIPAM45-stat-CMA5)-b-PGA42] diblock copolymer, which was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and ring-opening polymerization (ROP). The membrane of the vesicle consists of thermo-responsive PNIPAM and photo-cross-linkable PCMA. The PGA chains in the vesicle coronas can colloidally stabilize the vesicles in water and can be postfunctionalized for further applications. Transmission electron microscopy and dynamic light scattering studies confirmed the formation of vesicles. Overall, we prepared a new functional thermo-responsive vesicle based on polypeptide copolymers that may be used as nanocarriers for the facile loading of a range of molecules in future.

Key words: Vesicle, Peptide, Polymersome, Reversible addition fragmentation chain transfer, N-carboxyanhydride (NCA)


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