Acta Phys. -Chim. Sin. ›› 1997, Vol. 13 ›› Issue (07): 626-631.doi: 10.3866/PKU.WHXB19970710
• ARTICLE • Previous Articles Next Articles
Chen Hong-Ming,Zhou Jia-Ju,Xie Gui-Rong,Ren Tian-Rui
Received:
Revised:
Published:
Contact:
Abstract:
In this paper, PARM algorithm which can be used in QSAR research was put forward. In this algorithm, a set of pseudo atom was defined and a series of pseudo receptor model was generated by using genetic algorithm. These models which have high correlation between receptor-liagnd interaction and bioactivity can predict bioactivity of unknown molecules. This algorithm was used to investigate the K+ channel opener system. The reasonable results were obtained.
Key words: Pseudoreceptor model, Genetic algorithm, Quantitative structure-activity-relationship
Chen Hong-Ming,Zhou Jia-Ju,Xie Gui-Rong,Ren Tian-Rui. A QSAR Research Method Based on Pseudoreceptor Model[J].Acta Phys. -Chim. Sin., 1997, 13(07): 626-631.
0 /
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://www.whxb.pku.edu.cn/EN/10.3866/PKU.WHXB19970710
http://www.whxb.pku.edu.cn/EN/Y1997/V13/I07/626
Cited