Acta Phys. -Chim. Sin. ›› 2000, Vol. 16 ›› Issue (10): 926-931.doi: 10.3866/PKU.WHXB20001011

• ARTICLE • Previous Articles     Next Articles

Pharmacophore Model of ALS Inhibitors by DISCO Method

Miao Fang-Ming, Su Hua-Qing, Wang Jin-Ling, Li Ai-Xiu   

  1. Institute of Crystallography of Tianjin Normal University,Tianjin 300074|Medical Collage of Chinese People's Armed Police,Tianjin 300162
  • Received:2000-02-08 Revised:2000-06-06 Published:2000-10-15
  • Contact: Wang Jin-Ling


In this paper Pharmacophore Models of the interaction of four varieties of ALS inhibitors by distance comparison (DISCO) method with unknown three-dimensional structure of the receptor are reported. The Model not only conforms to our research requirement, but also helps to find a lot of unexpected biological information, which provides a theoretical guidance for the further design of new and more active ALS inhibitory herbicides and the active cavity simulation of its receptors.

Key words: ALS inhibitors, DISCO, Herbicide, Pharmacophore Model