Acta Phys. -Chim. Sin. ›› 2000, Vol. 16 ›› Issue (01): 80-86.doi: 10.3866/PKU.WHXB20000116

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Inhibition of Microemulsion of CTAB/n-C5H11OH/H2O System on the Hydrolysis of Penicillin-G Potassium

Qian Jun-Hong, Zhang Xiao-Hong, Guo Rong   

  1. Chemical Department,Yangzhou University,Science College,Yangzhou 225002
  • Received:1999-02-11 Revised:1999-06-01 Published:2000-01-15
  • Contact: Guo Rong


Penicillin-G potassium salt (Pen-K) shows hydrotropic action to the system of CTAB/ n-C5H11OH/H2O, due to the interaction between the polar groups of Pen-K and CTAB. Pen-K can be solubilized in the pro-oil side of the interphase of O/W and W/O microemulsion droplets, the water penetrating into the interphase of the droplets is prevented from contacting with Pen-K by n-C5H11OH which is solubilized in the polar group side, so that the stability of Pen-K was enhanced compared with that in water. However, Pen-K can not show hydrotropic action in SDS and Triton X-100 systems, and the hydrolytic rate of the Pen-K in the system of SDS and Triton X-100 is the same as that in water because of the effect of surfactant charge.

Key words: Microemulsion, Penicillin-G, Hydrolytic, Hydrotropic