Acta Phys. -Chim. Sin. ›› 2003, Vol. 19 ›› Issue (04): 368-371.doi: 10.3866/PKU.WHXB20030419

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Effect of Structurally-Specific Carboxylates on Biomineralization of Calcium Oxalate in Gel Systems

Ouyang Jian-Ming;Tan Yan-Hua;Shen Yu-Hua   

  1. Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632; College of Chemistry and Chemical Engineering, Anhui University, Hefei 230039
  • Received:2002-07-17 Revised:2002-10-17 Published:2003-04-15
  • Contact: Ouyang Jian-Ming E-mail:toyjm@jnu.edu.cn

Abstract: The effects of structurally-specific carboxylates on the crystallization of calcium oxalate(CaOx) were investigated in gel by a double diffusion technique. The ability to inhibit the aggregation of calcium oxalate monohydrate (COM) follows the sequence: tetracarboxylate (Na2EDTA) >tricarboxylate (sodium citrate) > dicarboxylate (sodium tartrate) >monocarboxylate (NaAc). The ability to induce calcium oxalate dihydrate (COD) follows the order: sodium citrate >sodium tartrate >Na2EDTA >NaAc. The counterions of carboxylic acids affected the crystallization of CaOx. The ability of both inhibiting the aggregation of COM and inducing the formation of COD follows the sequence: potassium citrate >> sodium citrate >citric acid. Both inhibiting the aggregation of COM and inducing the formation of COD can decrease the probability of the formation of urinary stones. These results may have positive significance in the prevention and cure of urinary stones.

Key words: Calcium oxalate, Urinary stone, Carboxylate, Gel