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Acta Physico-Chimica Sinica  2001, Vol. 17 Issue (07): 662-671    DOI: 10.3866/PKU.WHXB20010719
Review     
Some Relationships between Structures and Photodynamic Anti-cancer Activities of Phthalocyanines
Huang Jin-Ling;Huang Jian-Dong;Liu Er-Sheng;Chen Nai-Sheng
Institute of Research on Functional Materials, Department of Chemistry,Fuzhou U niversity, Fuzhou 350002
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Abstract  Photodynamic therapy (PDT) is a new and developing method for cancer t reatment involving the preferential uptake of a photosensitizer by tumor and its subsequent activation by light with appropriate wavelength. Phthalocyanines hav e received increasing attention as photosensitizers for PDT since 1985, so that several works have been focused on this area. This paper gives some relationship s between structures and photodynamic anti-cancer activities of phthalocyanines based on 51 related references. The emphasis is directed to the effects of cent ral ions and ring substitutents and axial ligands on the PDT activities and rela tive physical and chemical properties. The main conclusion is that the amphiphil ic character is the promising factor of phthalocyanines for PDT.

Key wordsPhthalocyanine      Photosensitizer for therapy of cancer      Photodynamic therapy      Structure-activity relationship     
Received: 06 December 2000      Published: 15 July 2001
Corresponding Authors: Huang Jin-Ling     E-mail: jdhuang@fzu.edu.cn
Cite this article:

Huang Jin-Ling;Huang Jian-Dong;Liu Er-Sheng;Chen Nai-Sheng. Some Relationships between Structures and Photodynamic Anti-cancer Activities of Phthalocyanines. Acta Physico-Chimica Sinica, 2001, 17(07): 662-671.

URL:

http://www.whxb.pku.edu.cn/10.3866/PKU.WHXB20010719     OR     http://www.whxb.pku.edu.cn/Y2001/V17/I07/662

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