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ISSN 1000-6818CN 11-1892/O6CODEN WHXUEU
Acta Phys Chim Sin >> 1995,Vol.11>> Issue(10)>> 925-928     doi: 10.3866/PKU.WHXB19951014         中文摘要
Study on the Quantitative Structure-activity Relationship of N1 Position of Quinolone
Zhu Long-Guan, Yu Qing-Sen, Chen Kai-Xian, Cai Cuo-Qiang, Lin Rui-Sen
Department of Chemistry,Zhejiang University,Hangzhou 310027|Shanghai Institute of Materia Medica,Academic Science of China,Shanghai 200031
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The steric and electrostatic effects of N1 substituted groups of fluoroquinolones and the way to find the new group with high activities by Comparative Molecular Field Analysis (CoMFA) have been studied. The results indicated that: (1) The activity of N1 position was mainly determinted by the steric effect, but the electrostatic effect is also important; (2) No new N1 substituted group with higher activity was found from the coefficient plots of CoMFA, which reflected the experimental results of late of years.



Keywords: Fluoroquinolone;QSAR;CoMFA  
Received: 1994-10-01 Accepted: 1995-01-10 Publication Date (Web): 1995-10-15
Corresponding Authors: Zhu Long-Guan Email:


Cite this article: Zhu Long-Guan, Yu Qing-Sen, Chen Kai-Xian, Cai Cuo-Qiang, Lin Rui-Sen. Study on the Quantitative Structure-activity Relationship of N1 Position of Quinolone[J]. Acta Phys. -Chim. Sin., 1995,11 (10): 925-928.    doi: 10.3866/PKU.WHXB19951014
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