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Acta Physico-Chimica Sinica  1995, Vol. 11 Issue (10): 925-928    DOI: 10.3866/PKU.WHXB19951014
Note     
Study on the Quantitative Structure-activity Relationship of N1 Position of Quinolone
Zhu Long-Guan, Yu Qing-Sen, Chen Kai-Xian, Cai Cuo-Qiang, Lin Rui-Sen
Department of Chemistry,Zhejiang University,Hangzhou 310027|Shanghai Institute of Materia Medica,Academic Science of China,Shanghai 200031
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Abstract  

The steric and electrostatic effects of N1 substituted groups of fluoroquinolones and the way to find the new group with high activities by Comparative Molecular Field Analysis (CoMFA) have been studied. The results indicated that: (1) The activity of N1 position was mainly determinted by the steric effect, but the electrostatic effect is also important; (2) No new N1 substituted group with higher activity was found from the coefficient plots of CoMFA, which reflected the experimental results of late of years.



Key wordsFluoroquinolone;QSAR;CoMFA     
Received: 01 October 1994      Published: 15 October 1995
Corresponding Authors: Zhu Long-Guan   
Cite this article:

Zhu Long-Guan, Yu Qing-Sen, Chen Kai-Xian, Cai Cuo-Qiang, Lin Rui-Sen. Study on the Quantitative Structure-activity Relationship of N1 Position of Quinolone. Acta Physico-Chimica Sinica, 1995, 11(10): 925-928.

URL:

http://www.whxb.pku.edu.cn/10.3866/PKU.WHXB19951014     OR     http://www.whxb.pku.edu.cn/Y1995/V11/I10/925

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