Acta Phys. -Chim. Sin. ›› 1995, Vol. 11 ›› Issue (12): 1077-1083.doi: 10.3866/PKU.WHXB19951204

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Study on Monolayer of Vitamin E and Phosphatidylcholines

Mo Feng-Kui,Wang Jing,Shogo Uematsu,Yukio Akahori   

  1. Department of Basic Courses,Shenyang Pharmaceutical University,Shenyang 110015|Department of Pharmaceutical Science,University of Shizuoka,Shizuoka,Japan 422
  • Received:1995-01-16 Revised:1995-05-09 Published:1995-12-15
  • Contact: Mo Feng-Kui

Abstract:

The surface pressure-area isotherms of mixed monolayers at the air/water interface have been determined for systems: d-α-, d-β-, d-γ-, and d-δ-tocopherol(TOC) with dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine(DOPC); d-α-TOC and cholesterol (CH) with dilinoleoylphosphatidylcholine (DLPC);and d-α-TOC with DPPC/DLPC (1:1/mol:mol). The effect of the chromanol methyl groups of vitamin E(VE) on its physicochemical behaviors in these monolayers had been discussed. It was observed that (1) TOC caused the DPPC monolayer to expand in the order ofα>β≈γ>δ, and the DOPC monolayer to condense in reverse order; (2) The collapse pressure of monolayer for DOPC and DLPC was not changed by TOC, while that of DPPC decreased; (3) Addition of d-α-TOC into the monolayer of equimolar mixture of DPPC and DLPC did not change the collapse pressure but produced an expanding effect; (4) Contrary to the generally accepted view, the physicochemical function of VE in mixed monolayer of phospholipids was obviously different from that of CH.

Key words: Monolayer, Vitamin E, Phosphatidylcholine, Tocopherol, Cholesterol, Surfacerol, Surface pressure