Acta Phys. -Chim. Sin. ›› 2005, Vol. 21 ›› Issue (10): 1143-1145.doi: 10.3866/PKU.WHXB20051016

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Functional Classification of Phospholipase A2 Family

LIU Zhen-ming; LI Bo; LAI Lu-hua   

  1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  • Received:2005-05-17 Revised:2005-06-08 Published:2005-10-15
  • Contact: LAI Lu-hua E-mail:lhlai@pku.edu.cn

Abstract: The affinity fingerprint method was used to functionally classify proteins based on the binding data matrix produced by multiple-docking. The method has been applied to the classification of phospholipase A2 enzymes. Though many of the classifications are similar to those from sequence alignment, the human cPLA2 was successfully grouped with bee PLA2 based on the binding site similarity, which can not be handled by sequence alignment due to cPLA2′s low homology with other PLA2s.

Key words: Affinity fingerprint, Multiple docking, Function-based protein classification