Acta Phys. -Chim. Sin. ›› 2004, Vol. 20 ›› Issue (10): 1196-1199.doi: 10.3866/PKU.WHXB20041006

• ARTICLE • Previous Articles     Next Articles

Influence of H on the Aggregation Properties of Sodium Deoxycholate Aqueous Solution

Zhang Li;Yang Zhan-Lan;Xiong Yao;Peng Teng-Teng;Weng Shi-Fu;Wu Jin-Guang   

  1. State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  • Received:2004-02-10 Revised:2004-05-20 Published:2004-10-15
  • Contact: Wu Jin-Guang E-mail:wjg@chem.pku.edu.cn

Abstract: The pH of bile is 6~8 in human gallbladder. The changes in pH will probably effect bile composition, which is important for gallstone formation. But little attention has been given to the influence of H+ on bile salts aggregates in aqueous solution. Our work focused on the changes of NaDC aggregates with adding H+ by using pH titration, FT-IR, UV-Vis and QELS (quasi-elastic light-scattering spectrometer) spectroscopies. The following conclusions are given: (1) With addition of H+ into NaDC aqueous solution above the cmc, The aggregation of NaDC micellar changes gradually into protonated micellar aggregates, secondary or mixed aggregates, and eventually gel-like precipitates.(2) The strong H-bond with the acid salt mode induces protonated micellar aggregation to connect with primary micelles of NaDC. (3) Therefore, aqueous micellar NaDC has a buffering capacity and can increase the solubility of HDC.

Key words: Sodium deoxycholate, pH titration, Micelle, H-bond influence