Acta Phys. -Chim. Sin. ›› 2009, Vol. 25 ›› Issue (03): 502-506.doi: 10.3866/PKU.WHXB20090317

• ARTICLE • Previous Articles     Next Articles

Solid-State Complexation of Cholic Acid and L-Phenylalanine

LIU Shi-Xiang, FANG Chun-Ying, LANG Zhe-Si, DAI Xing, WANG Xing-Feng, YANG Yun-Xu   

  1. Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, P. R. China
  • Received:2008-08-27 Revised:2008-12-19 Published:2009-03-02
  • Contact: YANG Yun-Xu E-mail:yxyang63@yahoo.com.cn

Abstract:

Solid-state complexation of cholic acid (CA)/L-phenylalanine (PAA) using a sealed-heating method was investigated. Powder X-ray diffractometry, IR spectroscopy, powder fluorescence spectroscopy, and differential thermal analysis (DTA) were used to characterize the CA-PAAcomplex. The result showed that PAA, as a guest, was assumed to be included in the channel of the complex formed by CA. While, grinding and co-precipitation methods were also compared to the sealed-heating method for the formation of the CA-PAA complex. It was shown that parts of the PAA were included into the channel of the CA complex during grinding and some solvents were also preferentially included into the guest compounds, which formed a stable cholic acid-solvent complex when co-precipitation method was used.

Key words: Cholic acid, L-Phenylalanine, Solid-state, Complexation

MSC2000: 

  • O645