Acta Phys. -Chim. Sin. ›› 2006, Vol. 22 ›› Issue (09): 1159-1162.doi: 10.3866/PKU.WHXB20060925

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Terahertz Time-Domain Spectroscopy of D-, L-, and DL- Penicillamines

JI Te;ZHAO Hong-Wei;ZHANG Zeng-Yan;GE Min;WANG Wen-Feng;YU Xiao-Han;XU Hong-Jie   

  1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China
  • Received:2006-02-14 Revised:2006-05-26 Published:2006-09-04
  • Contact: YU Xiao-Han E-mail:yuxh@sinap.ac.cn

Abstract: Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.

Key words: THz-TDS, D-, L-, and DL- penicillamines, Enantiomers, Quantitative analysis