Abstract:

Zeta potential of PC and PC-Cholesterol liposome was measured by microelectrophoretic mobility in the presence of different types of electrolyte. A combination of Gouy-Chapman-Stern theory and Poisson-Boltzmann equation was used to describe the regularity of the dependence of Zeta potential on several cations and anions with different valencies. Interaction mechanism of cation, anion and cholesterol with PC polar head group was discussed. The electrostatic force is dominated in influencing the surface potential of liposome.

Key words: Microelectrophoretic, Zeta potential, Phosphatidyl choline(PC), Cholesterol