Acta Phys. -Chim. Sin. ›› 1996, Vol. 12 ›› Issue (09): 849-851.doi: 10.3866/PKU.WHXB19960915

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Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug

Tan An-Min,Xu Bo,Qu Song-Sheng   

  1. Department of Chemsitry,Wuhan University,Wuhan 430072|National Key Laboratory of Natural and Biomimetric Drugs,Beijing 100083
  • Received:1996-01-29 Revised:1996-04-25 Published:1996-09-15
  • Contact: Qu Song-Sheng

Abstract:

Sp-Octyl-(8-Chloroadenosine)-3',5'-Cyclophosphate (OCC), a newlysynthesized cAMP analog, strongly induces growth inhibition and differentiation in human promyelocytic leukemia HL-60 cells. The effect of OCC is dose-time dependent. By using the LKB2277 Bioactivity Monitor, we determined the heat production rate of HL-60 cells treated by OCC at different concentrations. It was found that the heat production rate of HL-60 cell treated by OCC gradually decreased to that of normal human neutrophiles.

Key words: Microcalorimetry, OCC;HL-60 cells, Induced differentiation