Acta Phys. -Chim. Sin. ›› 2011, Vol. 27 ›› Issue (03): 539-546.doi: 10.3866/PKU.WHXB20110326

• THERMODYNAMICS, KINETICS, AND STRUCTURAL CHEMISTRY • Previous Articles     Next Articles

Design, Synthesis and Mimic Catalytic Activity of a Vanadium Haloperoxidase Conformation Model Molecule

CAO Yun-Zhu1, WEI Dong-Ming1, REN Dong-Xue1, CHEN Chen1, XING Yong-Heng1, SHI Zhan2   

  1. 1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, Liaoning Province, P. R. China;
    2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China
  • Received:2010-10-20 Revised:2011-01-07 Published:2011-03-03
  • Contact: XING Yong-Heng E-mail:yhxing2000@yahoo.com
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21071071), Education Foundation of Dalian City, China (2009J21DW004), and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, China (2010-15).

Abstract:

Based on mimicing the N, O coordination environment of the active center of vanadium haloperoxidase (V-HPOs) and the hydrogen-bond interaction between the active center and amino acid residues or water molecules, we designed and synthesized two kinds of oxidovanadium complexes: (C3H5N2)2[(VO)22-C2O4)(C2O4)2(H2O)2] (1) and (VO2)22- C2O4)(C2H4N2)2 (2). We determined their structures by X-ray single crystal diffraction. The crystal structure analysis indicated that the coordination environments of those oxidovanadium complexes were similar to the active center of vanadium haloperoxidase, and there seemed to be a mimicing α-helix structure in the three-dimensional packing structure of the complexes. Additionally, by studying the bromination reaction activity we found that the oxidovanadium complexes had an upper activity during the mimic catalytic process.

Key words: Vanadium haloperoxidase, Oxidovanadium complex, Crystal structure, α-Helix, Molecule conformation

MSC2000: 

  • O641