Acta Phys. -Chim. Sin. ›› 2012, Vol. 28 ›› Issue (02): 465-469.doi: 10.3866/PKU.WHXB201111291

• PHOTOCHEMISTRY AND RADIATION CHEMISTRY • Previous Articles     Next Articles

Synthesis, Fluorescence and DNA Photocleavage Activity of Phenothiazine-Corrole Gallium(III) Complexes

SHI Lei1,2, JIANG Huan-Feng2, YIN Wei1, WANG Hua-Hua2, WANG Hui3, ZHANG Lei2, JI Liang-Nian3, LIU Hai-Yang2   

  1. 1. Department of Chemistry, Guangdong University of Education, Guangzhou 510303, P. R. China;
    2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China;
    3. State Key Laboratory of Optoelectronics Materials and Technologies, Sun Yat-Sen University, Guangzhou 510275, P. R. China
  • Received:2011-10-13 Revised:2011-11-21 Published:2012-01-11
  • Contact: SHI Lei, LIU Hai-Yang E-mail:shil@gdei.edu.cn; chhyliu@scut.edu.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (20971046, 21171057, 61178037, 11004256), Natural Science Foundation of Guangdong Province, China (10351064101000000), Open Fund of the State Key Laboratory of Optoelectronic Materials and Technologies (Sun Yat-Sen University), China, and Appropriative Researching Fund for Professors and Doctors, Guangdong University of Education, China (10ARF14).

Abstract: Phenothiazine (PTZ)-corrole dyads 1-3 and their gallium(III) complexes 4-6 have been synthesized and characterized. The steady-state absorption and emission spectra and the time-resolved fluorescence decay profiles have been measured in toluene. The radiative and nonradiative rate constants have been obtained from the fluorescence quantum yields and monoexponential fluorescence lifetimes. The absorption spectra revealed that the gallium(III) corrole dyads exhibit stronger Soret bands and Q bands than free base corrole dyads. The fluorescence quantum yields of 1-3 are 0.156, 0.134, and 0.139, and the radiative rate constants are 4.02×107, 3.47×107, and 2.89×107 s-1, respectively. The fluorescence quantum yields of 4-6 are 0.502, 0.443, and 0.494, and the radiative rate constants are 20.9×107, 16.78×107, and 21.11×107 s-1, which are obviously higher than those of the corresponding free base corroles. The lifetimes of 4-6 are 2.40, 2.64, and 2.34 ns, respectively, which are somewhat shorter than those of the corresponding free base corroles. Agarose gel electrophoresis shows that these gallium(III) corrole dyads could cleave supercoiled DNA (form I) to give nicked-circular DNA (form II) under irradiation.

Key words: Corrole, Phenothiazine, Gallium(III), Fluorescence, DNA

MSC2000: 

  • O644