ISSN 1000-6818CN 11-1892/O6CODEN WHXUEU
Acta Phys Chim Sin >> 2012,Vol.28>> Issue(06)>> 1520-1524     doi: 10.3866/PKU.WHXB201203131         中文摘要
Cell Biocompatibility of Functionalized Graphene Oxide
ZHANG Xiao1,2, YANG Rong2, WANG Chen2, HENG Cheng-Lin1
1. Key Laboratory of Cluster Science of Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing 100081, P. R. China;
2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
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We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers’method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

Keywords: Graphene oxide   Nanomaterials   Biocompatibility   Surface functionalization  
Received: 2011-11-25 Accepted: 2012-03-11 Publication Date (Web): 2012-03-13
Corresponding Authors: YANG Rong, HENG Cheng-Lin Email:;

Fund: The project was supported by the National Natural Science Foundation of China (20911130229, 21073047) and Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences, China (KJCX2.YW.M15).

Cite this article: ZHANG Xiao, YANG Rong, WANG Chen, HENG Cheng-Lin. Cell Biocompatibility of Functionalized Graphene Oxide[J]. Acta Phys. -Chim. Sin., 2012,28 (06): 1520-1524.    doi: 10.3866/PKU.WHXB201203131
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