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ISSN 1000-6818CN 11-1892/O6CODEN WHXUEU
Acta Phys Chim Sin >> 2012,Vol.28>> Issue(10)>> 2390-2400     doi: 10.3866/PKU.WHXB201209111         中文摘要
BIOPHYSICAL CHEMISTRY
Protein-RNA Interaction Interface Prediction and Design
HUANG Yang-Yu, YANG Xiu-Feng, LI Hao-Tian, JI Xiao-Feng, CHENG Hong-Li, ZHAO Yun-Jie, GUO Da-Chuan, LI Lin, LIU Shi-Yong
Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, P. R. China
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RNA-protein interactions play key roles in many biological processes. The three dimensional (3D) structure of protein-RNA complexes can be determined experimentally by structural biologists. The recognition between protein and RNA can be understood from the 3D atomic structure. However, the structure determination of protein-RNA complexes by experimental methods is often difficult and costly, and limited to the binding strength. Thus, the prediction and design of protein-RNA complex structures is important in biological medical research. In this review, we will discuss the recent progress in protein-RNA interface prediction and design, which includes the following aspects: (1) protein-RNA docking and the conformational change on binding; (2) the recognition mechanism of protein-RNA binding; (3) the molecular design based on the protein-RNA interface. Improvement of the protein-RNA docking algorithm will help us annotate a large number of proteins and RNA with unknown function, and molecular design based on macromolecular interactions will be useful in drug design.



Keywords: Protein-RNA interaction   Molecular docking   Interface design   Complex structure prediction  
Received: 2012-08-23 Accepted: 2012-09-11 Publication Date (Web): 2012-09-11
Corresponding Authors: Email: liushiyong@gmail.com

Fund: The project was supported by the National Natural Science Foundation of China (31100522); and the National High Technology Research and Development Program of China (2012AA020402); and Specialized Research Fund for the Doctoral Program of Higher Education, China (20110142120038).

Cite this article: HUANG Yang-Yu, YANG Xiu-Feng, LI Hao-Tian, JI Xiao-Feng, CHENG Hong-Li, ZHAO Yun-Jie, GUO Da-Chuan, LI Lin, LIU Shi-Yong. Protein-RNA Interaction Interface Prediction and Design[J]. Acta Phys. -Chim. Sin., 2012,28 (10): 2390-2400.    doi: 10.3866/PKU.WHXB201209111

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