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Acta Phys. Chim. Sin.  2014, Vol. 30 Issue (1): 121-128    DOI: 10.3866/PKU.WHXB201311272
SOFT MATTER     
Preparation of Erythromycin-Imprinted Polymeric Microspheres by Emulsion Polymerization and Their Adsorption Properties
ZHAO Na, HU Xiao-Ling, GUAN Ping, SONG Ren-Yuan, TIAN Tian, ZHANG Xiang-Rong
The Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education, School of Natural and Applied Science, Northwestern Polytechnical University, Xi'an 710072, P. R. China
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Abstract  

Uniform molecularly imprinted polymeric microspheres (EM-MIPMs) were prepared by emulsion polymerization using erythromycin as the template molecule, methacrylic acid (MAA) as the functional monomer, and ethylene glycol dimethacrylate (EDMA) and sodium dodecylbenzene sulfonate (SBS) as the cross-linker and emulsifier, respectively. The obtained erythromycin-MAA complexes were characterized using ultraviolet (UV) absorption spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and 1H nuclear magnetic resonance (NMR) spectroscopy. The results showed that erythromycin-MAA complexes were obtained by cooperative hydrogen-bonding interactions. The surface features and thermal stability of the EM-MIPMs were investigated using scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA). The average diameter of the EM-MIPMs was 4.24 μm, larger than non-imprinted polymeric microspheres. They exhibited excellent thermal stability. Kinetic, equilibrium adsorption, and selectivity adsorption experiments (solid-phase extraction) were used to evaluate the binding properties and molecule recognition characteristics of EM-MIPMs for erythromycin. The experimental kinetic data were well described by a pseudo-second-order kinetic model. Erythromycin binding was examined using the Langmuir and Freundlich isotherm models. The EM-MIPMs had an excellent affinity for erythromycin. The equilibrium experimental data for the EM-MIPMs fitted the Langmuir isotherm well, and the binding amount reached 0.242 mmol·g-1. Furthermore, solid-phase extraction experiments demonstrated that the EM-MIPMs had a higher affinity for the target molecules than for roxithromycin and erythromycin ethylsuccinate.



Key wordsErythromycin      Molecularly imprinted microsphere      Adsorption      Binding property      Recognition property     
Received: 18 September 2013      Published: 27 November 2013
MSC2000:  O647  
  O641  
Fund:  

The project was supported by the National Natural Science Foundation of China (21174111).

Corresponding Authors: ZHAO Na     E-mail: zhaohx0906@126.com
Cite this article:

ZHAO Na, HU Xiao-Ling, GUAN Ping, SONG Ren-Yuan, TIAN Tian, ZHANG Xiang-Rong. Preparation of Erythromycin-Imprinted Polymeric Microspheres by Emulsion Polymerization and Their Adsorption Properties. Acta Phys. Chim. Sin., 2014, 30(1): 121-128.

URL:

http://www.whxb.pku.edu.cn/Jwk_wk/wlhx/10.3866/PKU.WHXB201311272     OR     http://www.whxb.pku.edu.cn/Jwk_wk/wlhx/Y2014/V30/I1/121

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