Acta Phys. -Chim. Sin. ›› 2014, Vol. 30 ›› Issue (7): 1363-1369.doi: 10.3866/PKU.WHXB201405063

• BIOPHYSICAL CHEMISTRY • Previous Articles     Next Articles

Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy

WANG Xin-Huan1,2, HAN Qiu-Sen2, LI Jing-Ying2, YANG Rong2, DIAO Guo-Wang1, WANG Chen2   

  1. 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China;
    2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • Received:2014-03-17 Revised:2014-05-06 Published:2014-06-30
  • Contact: YANG Rong, DIAO Guo-Wang, WANG Chen E-mail:yangr@nanoctr.cn;gwdiao@yzu.edu.cn;wangch@nanoctr.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21261130090, 21073047) and Special Fund for Pilot Technology of Chinese Academy of Sciences (XDA09030303).

Abstract:

We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammoniumbromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cell growth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.

Key words: Gold nanorod, Plasmon resonance absorption, Biocompatibility, Surface functionalization, Hyperthermia

MSC2000: 

  • O644