ISSN 1000-6818CN 11-1892/O6CODEN WHXUEU
Acta Phys Chim Sin >> 2017,Vol.33>> Issue(3)>> 476-485     doi: 10.3866/PKU.WHXB201611141         中文摘要
New Developments in Photoelectrochemical Bioanalysis
RUAN Yi-Fan, ZHANG Nan, ZHU Yuan-Cheng, ZHAO Wei-Wei, XU Jing-Juan, CHEN Hong-Yuan
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
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Photoelectrochemical (PEC) bioanalysis is a newly emerged and rapidly developing analysis technique that provides an elegant route for sensitive bioanalysis. The sensing mechanism of PEC bioanalysis is based on the fact that variations in photocurrent signal can be produced by biological interactions between various recognition elements and their corresponding targets. Owing to its excellent sensitivity, selectivity, and great potential for future bioanalysis, PEC bioanalysis has drawn increasing research attention and substantial progress has been made in its analytical applications. Currently, it has become a hot research topic and its recent momentum has grown rapidly, as demonstrated by the increased number of published research articles. Given the pace of advances in this area, this review first introduces the fundamentals and general instrumentation of this methodology. Then, with recent illustrative examples, we summarize the new developments in PEC bioanalysis according to its main bioanalytical applications, i.e., direct PEC detection of biomolecules, PEC enzymatic bioanalysis, PEC DNA detection, and PEC immunoassay. The future challenges and developments in this field are also discussed.

Keywords: Photoelectrochemistry   Bioanalysis   Enzyme   Nucleic acid   Immuno  
Received: 2016-10-12 Accepted: 2016-11-14 Publication Date (Web): 2016-11-14
Corresponding Authors: ZHAO Wei-Wei, XU Jing-Juan Email:;

Fund: The project was supported by the National Natural Science Foundation of China (21327902,21135003,21305063,21675080)

Cite this article: RUAN Yi-Fan, ZHANG Nan, ZHU Yuan-Cheng, ZHAO Wei-Wei, XU Jing-Juan, CHEN Hong-Yuan. New Developments in Photoelectrochemical Bioanalysis[J]. Acta Phys. -Chim. Sin., 2017,33 (3): 476-485.    doi: 10.3866/PKU.WHXB201611141

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29. SUN Wei-Qi, ZHANG Ji-Long, ZHENG Qing-Chuan, SUN Zhi-Wei, ZHANG Hong-Xing.Molecular Dynamics Simulations of the Unbinding of Phenylsulfonamide from Carbonic Anhydrase II[J]. Acta Phys. -Chim. Sin., 2013,29(04): 843-848
30. YANG Li-Jun, LIU Qian, YUAN Wen-Bin, YANG Sheng-Yong.Molecular Dynamics Simulations of Interactional Mechanism and Binding Energy Calculations between Kinase ABL and Small Molecules Binding at Myristoyl Pocket[J]. Acta Phys. -Chim. Sin., 2013,29(02): 423-430
31. BAI Shu, ZHOU Rong, LIU Fu-Feng.Rational Design of Affinity Ligand for the Oriented Immobilization of Trypsin[J]. Acta Phys. -Chim. Sin., 2013,29(02): 439-448
32. LÜ Wei, XUE Ying, MENG Qing-Wei.Classification Prediction of Inhibitors of H1N1 Neuraminidase by Machine Learning Methods[J]. Acta Phys. -Chim. Sin., 2013,29(01): 217-223
33. YU Zhi-Hui, SU Ting-Ting, REN Cui-Hua, LI Fan, XIA Ding-Guo, CHENG Shui-Yuan.Direct Electrochemistry and Immobilization of Glucose Oxidase on Nano-Carbon Aerogels[J]. Acta Phys. -Chim. Sin., 2012,28(12): 2867-2873
34. LI Wei-Bing, BU Yu-Yu, YU Jian-Qiang.Preparation of ZnO/In2O3 Composite Hollow Spheres and Their Photoelectrocatalytic Properties to Glucose Degradation[J]. Acta Phys. -Chim. Sin., 2012,28(11): 2676-2682
35. HE Chuan-Xin, YUAN An-Peng, ZHANG Qian-Lin, REN Xiang-Zhong, LI Cui-Hua, LIU Jian-Hong.Adsorption of Core-Shell Poly(Methyl Methacrylate)-Bovine Serum Albumin Nanoparticles on Gold Surface and Its Sensor Application[J]. Acta Phys. -Chim. Sin., 2012,28(11): 2721-2728
36. HUANG Yong-Qi, KANG Xue, XIA Bing, LIU Zhi-Rong.Mechanism of 3D Domain Swapping for Mpro-C: Clues from Molecular Simulations[J]. Acta Phys. -Chim. Sin., 2012,28(10): 2411-2417
37. ZHOU Lu, JIN Feng, LIU Ying SHANG Er-Chang, WEI Ping, LI Chun-Mei, LAI Lu-Hua.Isatin Dual Functional Inhibitors: Modulating the Aggregation State and Enzyme Activity of SARS-3CL Proteinase[J]. Acta Phys. -Chim. Sin., 2012,28(10): 2418-2422
38. LUO Fang, GAO Jian, CHENG Yuan-Hua, CUI Wei, JI Ming-Juan.Interaction Mechanisms of Inhibitors of Glucoamylase by Molecular Dynamics Simulations and Free Energy Calculations[J]. Acta Phys. -Chim. Sin., 2012,28(09): 2191-2201
39. LI Jin-Hua, LI JING, FANG Xuan, WANG Xiao-Hua, WEI Zhi-Peng.Fabrication and Characteristic of ZnO Glucose Oxidase Enzyme Electrode Based on Flexible Substrate[J]. Acta Phys. -Chim. Sin., 2012,28(06): 1393-1397
40. HUANG Ye, LIU Yu-Yang, LI Wen-Zhang, CHEN Qi-Yuan.Effects of Calcination Temperature on Morphologies and Photoelectrochemical Properties of Anodized WO3 Nanoporous Films[J]. Acta Phys. -Chim. Sin., 2012,28(04): 865-870
41. ZHANG Xiao-Yan, SUN Ming-Xuan, SUN Yu-Jun, LI Jing, SONG Peng, SUN Tong, CUI Xiao-Li.Photoelectrochemical Properties of Graphene Oxide Thin Film Electrodes[J]. Acta Phys. -Chim. Sin., 2011,27(12): 2831-2835
42. YUE Zhao, ZHANG Wei, WANG Cheng, LIU Guo-Hua, NIU Wen-Cheng.Photoinduced Electron Transfer between CdS Quantum Dots and Gold Electrodes[J]. Acta Phys. -Chim. Sin., 2011,27(12): 2814-2820
43. LEI Qing-Juan, GAO Bao-Jiao, ZHANG Zheng-Guo.Action Mechanism of Secondary Bond Forces on Chemical Immobilization of Horseradish Peroxidase[J]. Acta Phys. -Chim. Sin., 2011,27(11): 2697-2704
44. BU Yu-Yu, LI Wei-Bing, YU Jian-Qiang, WANG Xiu-Tong, QI Mei-Ling, NIE Meng-Yan, HOU Bao-Rong.Fabrication of SrTiO3 Nanocrystalline Film Photoelectrode and Its Photoelectrochemical Anticorrosion Properties for Stainless Steel[J]. Acta Phys. -Chim. Sin., 2011,27(10): 2393-2399
45. GAO Yun-Yan, LI Hai-Xia, OU Zhi-Ze, HAO Ping, LI Yi, YANG Guo-Qiang.Enhancing the Catalytic Activity of Peroxidase by Adsorption onto Fe3O4 Magnetic Nanoparticle/Multiwalled Carbon Nanotube Composite Surfaces[J]. Acta Phys. -Chim. Sin., 2011,27(10): 2469-2477
46. PENG Tian-You, KE Ding-Ning, ZENG Peng, ZHANG Xiao-Hu, FAN Ke.Preparation and Photoelectrochemical Performance of BiVO4 Film Electrode[J]. Acta Phys. -Chim. Sin., 2011,27(09): 2160-2166
47. ZHI Ze-Yong, LIU Peng-Cheng, HUANG Yan-Yi, ZHAO Xin-Sheng.A Microfluidic Mixer for Single-Molecule Kinetics Experiments[J]. Acta Phys. -Chim. Sin., 2011,27(08): 1990-1995
48. SHEN Tao, DU Feng-Pei, LIU Ting, YAO Guang-Wei, WU Zheng, FANG Meng-Meng, XU Xiao-Jie, LU Hui-Zhe.Molecular Simulation of the Interaction between Imidazole Glycerol Phosphate Dehydrase and Nitrogen-Containing Heterocyclic Phosphate Inhibitors[J]. Acta Phys. -Chim. Sin., 2011,27(08): 1831-1838
49. KANG Xue-Li, CHEN Qi-Bin, SHANG Ya-Zhuo, LIU Hong-Lai.Interaction between Gemini and DNA at the Air/Water Interface[J]. Acta Phys. -Chim. Sin., 2011,27(06): 1467-1473
50. FAN Di, LIU Zhen-Ming, JIN Hong-Wei, ZHANG Liang-Ren.Classification of Coenzyme-A Binding Proteins Based on Co-Factor Binding Modes[J]. Acta Phys. -Chim. Sin., 2011,27(05): 1223-1231
51. WANG Zhi-Ping, LUO Hong, GAO Li-Hua, WANG Ke-Zhi.Electrostatically Self-Assembled Films Prepared Using Bipolar Thiophene Hemicyanine and Prussian Blue[J]. Acta Phys. -Chim. Sin., 2011,27(03): 754-758
52. CAO Yun-Zhu, WEI Dong-Ming, REN Dong-Xue, CHEN Chen, XING Yong-Heng, SHI Zhan.Design, Synthesis and Mimic Catalytic Activity of a Vanadium Haloperoxidase Conformation Model Molecule[J]. Acta Phys. -Chim. Sin., 2011,27(03): 539-546
53. LI Min-Jie, LIU Wei-Xia, PENG Chun-Rong, LU Wen-Cong.A First-Principles Method for Predicting Redox Potentials of Nucleobases and the Metabolites in Aqueous Solution[J]. Acta Phys. -Chim. Sin., 2011,27(03): 595-603
54. WANG Dan, ZHANG Yan-Ling, QIAO Yan-Jiang.Support Vector Machine and KStar Models Predict the o-Dealkylation Reaction Mediated by Cytochrome P450[J]. Acta Phys. -Chim. Sin., 2011,27(02): 343-351
55. LUO Ying, CUI Xiao-Li, XIE Jing-Ying.Preparation and Visible Light Photoelectrochemical Response of TiO2-MoO3 Composite Nanotube Thin Films[J]. Acta Phys. -Chim. Sin., 2011,27(01): 135-142
56. SUN Hao, JIANG Yong-Jun, YU Qing-Sen, GAO Hui.Molecular Dynamics Simulations on the Role of Structural Mg2+ Ions in Phosphoryl Transfer Catalyzed by GSK-3β[J]. Acta Phys. -Chim. Sin., 2011,27(01): 207-212
57. HAO Ping, GAO Yun-Yan, OU Zhi-Ze, LI Yi, WANG Zhong-Li, WANG Xue-Song.Preparation of Aminopyridine Grafted Carbon Nanotube and Its Interaction with Horseradish Peroxidase[J]. Acta Phys. -Chim. Sin., 2011,27(01): 233-240
58. YANG Guo-Bing, LI Ze-Rong, RAO Han-Bing, LI Xiang-Yuan, CHEN Yu-Zong.Classification Models for Acetylcholinesterase Inhibitors Based on Machine Learning Methods[J]. Acta Phys. -Chim. Sin., 2010,26(12): 3351-3359
59. ZENG Han, LIAO Ling-Wen, LI Ming-Fang, TAO Qian, KANG Jing, CHEN Yan-Xia.Poly Aryl Amide and Multiwalled Carbon Nanotube Composite Supported Laccase Electrode and Its Electrochemical Behavior[J]. Acta Phys. -Chim. Sin., 2010,26(12): 3217-3224
60. ZHANG Qiao-Bao, FENG Zeng-Fang, HAN Nan-Nan, LIN Ling-Ling, ZHOU Jian-Zhang, LIN Zhong-Hua.Preparation and Photoeletrochemical Performance of CdS Quantum Dot Sensitized ZnO Nanorod Array Electrodes[J]. Acta Phys. -Chim. Sin., 2010,26(11): 2927-2934
61. ZHOU Wen-Wen, LIAN Jie, HU Ke-Jia, GAO Yun-Hua, XU Bai.Effect of Surface Chemical Properties of a Silicon Chip on Antibody Immobilization[J]. Acta Phys. -Chim. Sin., 2010,26(10): 2821-2827
62. LI Wen-Zhang, LI Jie, WANG Xuan, ZHANG Shu-Juan, CHEN Qi-Yuan.Photoelectrochemical Properties of Cubic Tungsten Trioxide Films Obtained by the Polymeric Precursor Method[J]. Acta Phys. -Chim. Sin., 2010,26(09): 2343-2348
63. LI Qiang-Gen, XUE Ying, GUO Yong, YAN Guo-Sen.Phosphonylation and Activity Loss Mechanism of the Catalytic Triad of Fatty Acid Amide Hydrolase: Theoretical Study of a Model System[J]. Acta Phys. -Chim. Sin., 2010,26(07): 1965-1975
64. SU Xiao-Dong, JIN Jian-Shi, XIE Sunney Xiaoliang.Enzyme Catalysis and Gene Expression Studies at Single Molecule Level[J]. Acta Phys. -Chim. Sin., 2010,26(07): 1976-1987
65. ZHANG Yuan, CHEN Ya-Dong, YOU Qi-Dong, ZOU Li-Yun, YANG Yan.Homology Modeling and Molecular Docking Studies on the Selectivity of HDAC1/HDAC8[J]. Acta Phys. -Chim. Sin., 2010,26(06): 1676-1686
66. YIN Guo-Wei, WEI Wei, XU Jia, LI Zhi-Fen, WANG Bao-Huai, DU Wei-Hong.Interaction of Nickel(II) with Yeast Alcohol Dehydrogenase[J]. Acta Phys. -Chim. Sin., 2010,26(04): 1107-1112
67. LIU Ping, XING Guo-Wen, LI Xuan-Wen, YE Yun-Hua.Adsorptive Immobilization of Four Proteases on Different Molecular Sieves[J]. Acta Phys. -Chim. Sin., 2010,26(04): 1113-1118
68. WEI Ping, LI Chun-Mei, ZHOU Lu, LIU Ying, LAI Lu-Hua.Substrate Binding and Homo-Dimerization of SARS 3CL Proteinase are Mutual Allosteric Effectors[J]. Acta Phys. -Chim. Sin., 2010,26(04): 1093-1098
69. LV Wei, XUE Ying.Activity Prediction of Hormone-Sensitive Lipase Inhibitors Based on Machine Learning Methods[J]. Acta Phys. -Chim. Sin., 2010,26(02): 471-477
70. FU Hong-Yan, GAO Bao-Jiao, NIU Qing-Yuan.Adsorption Behavior and Mechanism of Grafted PMAA-HEMA/NVP Microspheres toward Lysozyme[J]. Acta Phys. -Chim. Sin., 2010,26(02): 359-366
71. JIANG Lei, HUANG Hui, WANG Chun-Tao, ZHANG Wen-Kui, GAN Yong-Ping, TAO Xin-Yong.Photoelectrochromic Properties of TiO2-xNx/NiO Bilayer Thin Films[J]. Acta Phys. -Chim. Sin., 2010,26(02): 299-303
72. LI Shu-Bai, NIE Hua-Li, ZHANG Hai-Tao, XUE Yong, CHRIS Branford White, ZHU Li-Min.Inhibitory Kinetics of a Trifluoromethyl-Containing 1,2,3-Triazole Derivative on Mushroom Tyrosinase Activity[J]. Acta Phys. -Chim. Sin., 2010,26(01): 215-220
73. LI Wen, LENG Wen-Hua, NIU Zhen-Jiang, LI Xiang, FEI Hui, ZHANG Jian-Qing, CAO Chu-Nan.Enhanced Photoelectrochemical Performance of WO3 Film Electrode under Visible Light by Electrochemical Etching Fluorination in Aqueous Solutions Containing Fluorine[J]. Acta Phys. -Chim. Sin., 2009,25(12): 2427-2432
74. MA Guo-Xian, ZHONG Qing-Dong, LU Xiong-Gang, LU Tian-Hong.Immobilization and Direct Electrochemistry of Horseradish Peroxidase on Large Cage-Like Mesoporous Silica FDU-12[J]. Acta Phys. -Chim. Sin., 2009,25(10): 2061-2067
75. JIANG Yu-Ren, XU Hui, CHEN Fang-Jun, MA Guan-Jun.Molecular Docking of the Acetylcholinesterase Inhibitor Corydaline and Virtual Screening of Open Ring Derivatives[J]. Acta Phys. -Chim. Sin., 2009,25(07): 1379-1384
76. WEI Zhuo, ZHANG Huai, CUI Wei, JI Ming-Juan.Molecular Docking and 3D-QSAR on Maleimide Derivatives as Glycogen Synthase Kinase-3β Inhibitors[J]. Acta Phys. -Chim. Sin., 2009,25(05): 890-896
77. ZHANG Xiao-Yi, LIU Bin, HE Hong-Qiu, YANG Dong, WANG Cun-Xin.Human Immunodeficiency Virus Integrase Pharmacophore Model Derived from Diketoacids Inhibitors[J]. Acta Phys. -Chim. Sin., 2009,25(05): 817-824
78. CUI Wei, ZHANG Huai, JI Ming-Juan.Molecular Dynamics Simulations and Free Energy Calculations of a Novel Series of Protein Tyrosine Phosphatase 1B Difluoromethylenephosphonic Acid Inhibitors[J]. Acta Phys. -Chim. Sin., 2009,25(04): 668-676
79. SUN Ni-Yue, LU Tao, CHEN Ya-Dong, HAO Lan-Hu, XU Yan, LI Rui-Jun.3D-QSAR and Molecular Docking Study on Selectivity of Indolocarbazole Series as Cyclin-Dependent Kinase Inhibitors[J]. Acta Phys. -Chim. Sin., 2009,25(04): 645-654
80. SUN Hao, JIANG Yong-Jun, YU Qing-Sen, ZOU Jian-Wei.Molecular Dynamics Simulation of Significant Roles of Structural Water Molecules in Glycogen Synthase Kinase-3β[J]. Acta Phys. -Chim. Sin., 2009,25(04): 635-639
81. ZHAO Yong-Shan, ZHENG Qing-Chuan, ZHANG Hong-Xing, CHU Hui-Ying, SUN Chia-Chung.Homology Modeling of Human Serine Racemase and Its Molecular Docking with Peptide Inhibitors[J]. Acta Phys. -Chim. Sin., 2009,25(03): 417-422
82. YU Zhi-Yong; ZHANG Wei; MA Ming; CUI Xiao-Li.Visible Light Photoelectrochemical Response of Nitrogen-Doped TiO2 Thin Films Prepared by Anodic Oxidation of Titanium Nitride Films[J]. Acta Phys. -Chim. Sin., 2009,25(01): 35-40
83. ZHANG Wei; CUI Xiao-Li; JIANG Zhi-Yu.Effect of Composite Modes on Photoelectrochemical Properties of MWCNTs/TiO2 Nanocomposite Films[J]. Acta Phys. -Chim. Sin., 2008,24(11): 1975-1980
84. HU Jian-Ping; KE Guo-Tao; CHANG Shan; CHEN Wei-Zu; WANG Cun-Xin.Conformational Change of HIV-1 Viral DNA after Binding with Integrase[J]. Acta Phys. -Chim. Sin., 2008,24(10): 1803-1810
85. SUN Yi; XU Juan; CAI Wen-Bin; JIANG Zhi-Yu.Mechanism of Photokilling LoVo Cells by Nano TiO2 Photocatalytic Oxidation Combined with Immunity and Electroporation Method[J]. Acta Phys. -Chim. Sin., 2008,24(08): 1359-1365
86. CUI Bao-Qiu; GONG Li-Dong; ZHAO Dong-Xia.Molecular Dynamics Simulation of Microperoxidase in Aqueous Solution in Terms of the ABEEM/MM Method[J]. Acta Phys. -Chim. Sin., 2008,24(06): 1035-1040
87. CHEN Qiao-Lin; ZHOU Jian-Zhang; LIANG Jin-Ling; LIN Ling-Ling; LIN Zhong-Hua.Spectroscopic and Photoelectrochemical Properties of DNA/CdS Nanoparticle Composites[J]. Acta Phys. -Chim. Sin., 2008,24(05): 749-754
88. ZHU Lv-Jun; XU Qun-Jie; CAO Wei-Min; WAN Zong-Yue; ZHOU Guo-Ding; LIN Chang-Jian.Photoelectrochemical Study on the Complex of PASP and Tungstate as Inhibitors of Cupronickel B10’s Corrosion[J]. Acta Phys. -Chim. Sin., 2008,24(05): 805-809
89. BAO Hong-Juan; ZHANG Yan-Ling; QIAO Yan-Jiang.Pharmacophore Model Generation of HMG-CoA Reductase Inhibitors[J]. Acta Phys. -Chim. Sin., 2008,24(02): 301-306
90. MAN Yi; ZONG Rui-Long; ZHU Yong-Fa.Preparation and Photoelectrochemical Properties of Bi2MoO6 Films[J]. Acta Phys. -Chim. Sin., 2007,23(11): 1671-1676
91. ZHU Lei; CUI Xiao-Li; SHEN Jie; YANG Xi-Liang; ZHANG Zhuang-Jian.Visible Light Photoelectrochemical Response of Carbon-doped TiO2 Thin Films Prepared by DC Reactive Magnetron Sputtering[J]. Acta Phys. -Chim. Sin., 2007,23(11): 1662-1666
92. ZHANG Yu-Xia; ZHAO Ji-Hua; DU Zhong-Yu; FANG Jian; AN Xue-Qin; SHEN Wei-Guo.Enzymatic Activity of Candida Rugosa Lipase in an AOT/Triton X-100 Mixed Reverse Micellar System[J]. Acta Phys. -Chim. Sin., 2007,23(09): 1483-1486
93. SHI Ya-Wei; LIU Zhen-Ming; JIN Hong-Wei; ZHANG Liang-Ren; ZHANG Li-He.Quantitative Structure-Activity Relationships of HIV-1 Integrase Inhibitors of DKAs[J]. Acta Phys. -Chim. Sin., 2007,23(09): 1393-1398
94. CHEN Xin; ZHANG Yi-Li; SU Yu-Hua; MENG Wen-Hua; XIE Qing-Ji; YAO Shou-Zhuo.EQCM Studies on Enzymatic Specific Activities of Glucose Oxidase Adsorbed on Au-electroplated and Carbon Nanotubes-modified Au Electrodes[J]. Acta Phys. -Chim. Sin., 2007,23(08): 1201-1206
95. LIU Hai-Bo; WANG Zhan-Li; QIAO Ying-Xin; ZHOU Jia-Ju.Flavonoids with Aldose Reductase Inhibiting Activity: PharmacophoreModeling and Implications forMechanism[J]. Acta Phys. -Chim. Sin., 2007,23(07): 1059-1064
96. MA Guo-Xian; ZHONG Hui; LU Tian-Hong; XIA Yong-Yao.Direct Electrochemistry and Immobilization of Glucose Oxidase on Carbon Black[J]. Acta Phys. -Chim. Sin., 2007,23(07): 1053-1058
97. FANG Ying-Ying; HU Xin-Gen; YU Li; LI Wen-Bing; ZHU Yu-Qing; YU Sheng.Effect of DMSO on Denaturation of Hen Egg-white Lysozyme in Aqueous Solution[J]. Acta Phys. -Chim. Sin., 2007,23(07): 1025-1031
98. GUO Xiao-Li; GUO Min; WANG Xin-Dong.Bienzymatic Glucose Biosensor Based on Graphite Electrode Modified with Nanofibrous Polyaniline[J]. Acta Phys. -Chim. Sin., 2007,23(04): 585-589
99. FANG Ying-Ying;HU Xin-Gen;YU Li;LI Wen-Bing;LIN Rui-Sen.Study on Thermal Denaturation of Lysozyme by DSC[J]. Acta Phys. -Chim. Sin., 2007,23(01): 84-87
100. ZHANG Shi-Cheng;YAO Wen-Qing;ZHU Yong-Fa;SHI Li-Yi.Preparation and Photoelectrochemical Properties of Bi2WO6 Films with Visible Light Response[J]. Acta Phys. -Chim. Sin., 2007,23(01): 111-115
101. LIU Hui-Hong;WAN Yong-Qing;CHEN Xian-Tang;ZOU Guo-Lin.Electrochemistry of Immobilized Horseradish Peroxidase in Organic Solvents/Water Mixture[J]. Acta Phys. -Chim. Sin., 2006,22(07): 868-872
102. LIANG Gui-Zhao; MEI Hu; ZHOU Peng; ZHOU Yuan; LI Zhi-Liang.Study on Quantitative Structure-Activity Relationship by 3D Holographic Vector of Atomic Interaction Field[J]. Acta Phys. -Chim. Sin., 2006,22(03): 388-390
103. LIU Ling; ZHAO Yao-Min; YANG Jie; ZHAO Chong-Jun; JIANG Zhi-Yu.Photoeletrochemical Behavior of Polypyrrole Nanofiber Array Electrodes[J]. Acta Phys. -Chim. Sin., 2006,22(03): 261-264
104. YAN Hao; JIANG Feng-Chao.Pharmacophore Model Construction of γ-secretase Inhibitor[J]. Acta Phys. -Chim. Sin., 2006,22(03): 359-364
105. HAO Yan-Zhong; HAN Wen-Tao.Preparation and Photoelectrochemical Properties of Titanate Nanotubes[J]. Acta Phys. -Chim. Sin., 2006,22(02): 221-225
106. HAO Yan-Zhong;CAI Chun-Li.A Photoelectrochemical Study of the Nanostructured TiO2 /P3HT Film Electrode[J]. Acta Phys. -Chim. Sin., 2005,21(12): 1395-1398
107. LIU Chun-li; LI Chun-hua; CHEN Wei-zu; WANG Cun-xin.Study on Interaction between HIV-1 Integrase and Its Dicaffeoyl Inhibitors through Molecular Modeling Approach[J]. Acta Phys. -Chim. Sin., 2005,21(11): 1229-1234
108. SHI Jing-ying; LENG Wen-hua; CHENG Xiao-fang; ZHANG Jian-qing; CAO Chu-nan.Photocatalytic Oxidation of Methyl Red by TiO2 in a Photoelectrochemical Cell[J]. Acta Phys. -Chim. Sin., 2005,21(09): 971-976
109. LIU Hai-chun; ZOU Jian-wei; ZHANG Bing; ZHUANG Shu-lin; JIANG Yong-jun; YU Qing-sen.Homology Modeling of p-Hydroxymandelate Synthase and Its Molecular Docking with Substrate[J]. Acta Phys. -Chim. Sin., 2005,21(08): 852-856
110. LIAO Wei; HONG Long; WEI Fang; ZHU Sheng-Geng; ZHAO Xin-Sheng.Improving Phage Antibody Chip by pⅧ Display System[J]. Acta Phys. -Chim. Sin., 2005,21(05): 508-511
111. ZHANG, Jin1 TANG Ying; XIE Jia-Qing; LI Jian-Zhang; ZENG, Xian-Cheng; HU Chang-Wei.Kinetics of BNPP Hydrolysis Catalyzed by the Metallomicelle Based on Crown Schiff Base Complex[J]. Acta Phys. -Chim. Sin., 2005,21(04): 408-413
112. LIU Bing; LU Ai-Jun; LIAO Chen-Zhong; LIU Hai-Bo; ZHOU Jia-Ju.3D-QSAR of Sulfonamide Hydroxamic Acid HDAC Inhibitors[J]. Acta Phys. -Chim. Sin., 2005,21(03): 333-337
113. Chen Zhi-Chun;Xu Shan-Hao;Lin Han-Feng;Yang Shao-Ming;Lin Xian-Fu.Glucose Oxidase Modified Electrode Fabricated by Layer-by-layer Molecular Deposition[J]. Acta Phys. -Chim. Sin., 2004,20(10): 1267-1270
114. Song Ji-Guo;Shen Pei-Kang.Electrochemical Characterization of Copper Paratolylsulfonate[J]. Acta Phys. -Chim. Sin., 2004,20(10): 1216-1220
115. Wang Yan-Hua;Zou Jian-Wei;Hu Gui-Xiang;Zheng Ke-Wen;Yu Qing-Sen.Theoretical Studies on the Nucleophilic Additions of Mimic Compounds of Pyrroloquinoline Quinone with Ammonia[J]. Acta Phys. -Chim. Sin., 2004,20(09): 1129-1133
116. Chen Ting-Ting;Huang Xiao-Hua;Du Jiang-Yan;Feng Yu-Ying;Liu Chang-Peng;Xing Wei;Lu Tian-Hong.Study on the Interaction Strength of La3+ or Eu3+ with Microperoxidase-8[J]. Acta Phys. -Chim. Sin., 2004,20(08): 887-891
117. Guo Jia-Hao;He Xiao-Ying;Guo Min;Cai Sheng-Min;Chen Xiu-Ying;Peng Xiao-Jun.Photoelectrochemical Studies of the TiO2 Nanocrystalline Electrode Sensitized by Novel Cyanine Dye[J]. Acta Phys. -Chim. Sin., 2004,20(08): 849-853
118. Zheng Ke-Wen;Yu Qing-Sen;Zeng Min;Ma Guo-Zheng;Wang Yan-Hua;Zhang Bing.Efffects of Electrostatic and Hydrophobic Interaction on the Stability of the TGEV Main Proteinase Dimer[J]. Acta Phys. -Chim. Sin., 2004,20(06): 587-592
119. Xie Ai-Hua;Li Bo-Yu;Liao Chen-Zhong;Li Zhi-Bin;Lu Xian-Ping;Shi Le-Ming;Zhou Jia-Ju.Docking Study of HDAC Implication for Benzamide Inhibitors Binding Mode[J]. Acta Phys. -Chim. Sin., 2004,20(06): 569-572
120. Li Yang-Mei;Jiang Xiu-Ming;Chen Zhi-Chun;Fu Shui-Yu;Lin Xian-Fu.Construction of Ordered Films of Horseradish Peroxidase through Lectin-glycogenReaction and Its Application in Enzyme Electrode[J]. Acta Phys. -Chim. Sin., 2004,20(02): 216-220
121. Peng Tao;Zhou Jia-Ju.Pharmacophore-based 3D Database Searching[J]. Acta Phys. -Chim. Sin., 2003,19(09): 886-888
122. Mu Shao-Lin;Yang Yi-Fei;Tan Zhi-An.The Electrocatalytic Oxidation of Hydrogen Peroxide on Polyaniline Doped with Ferrocenesulfonic Acid[J]. Acta Phys. -Chim. Sin., 2003,19(07): 588-592
123. Zhang Guo-Lin;Pan Xian-Hua;Kan Jin-Qing;Zhang Jing-Hui;Li Yong-Fang.Studies on Conducting Composite MaterialGlucose Oxidase Biosensor[J]. Acta Phys. -Chim. Sin., 2003,19(06): 533-537
124. Li Yang-Mei;Chen Zhi-Chun;Lü De-Shui;Lin Xian-Fu.Topography and Electro-catalysis Property of Horseradish Peroxidase Assembly Active Films[J]. Acta Phys. -Chim. Sin., 2003,19(05): 474-477
125. Peng Tao;Pei Jian-Feng;Zhou Jia-Ju.Three-dimensional Quantitative Structure-Activity Relationship Study of Tyrosine Kinase Inhibitors[J]. Acta Phys. -Chim. Sin., 2003,19(02): 163-166
126. Huang Chang-Kang;Gao Ying;Liu Zhen-Ming;Liu Ying;Lai Lu-Hua.Comparative Molecular Field Analysis of Pyrrolidine Inhibitors for Human Cytosolic Phospholipase A2[J]. Acta Phys. -Chim. Sin., 2003,19(01): 79-81
127. Zhang Hong-Lin;Yu Xiu-Fang;Zhang Gang.Thermokinetics of Activation of Metal Ions to Amylase Catalyzed Reaction[J]. Acta Phys. -Chim. Sin., 2002,18(12): 1125-1128
128. Gao Hong-Wen;Zi Yan-Qin;Li Yu-Cheng.Langmuir Aggregation of Polychrome Blue on Nucleic Acids[J]. Acta Phys. -Chim. Sin., 2002,18(06): 540-544
129. Wang Feng-Bin;Jiang Hui-Jun;Xing Wei;Lu Tian-Hong;Chen Hui-Lan.Electrochemical and Electrocatalytic Properties of Microperoxidase-11 Adsorbed on the Poly-L-Lysine Modified Ag Electrode[J]. Acta Phys. -Chim. Sin., 2002,18(05): 404-408
130. Zhao Zhuan-Qing;Yao Su-Wei;Zhang Wei-Guo;Gong Zheng-Lie.Preparation and Photoelectrochemical Performance of Photoelectrode of TiO2 Film on Nickel[J]. Acta Phys. -Chim. Sin., 2002,18(05): 473-476
131. Dai Guo-Liang;Dong Xiang-Qun;Sun Zhi-Wei;Hu Wen-Rui.The Effect of Vapor Diffusion Rate on Lysozyme Crystal Growth[J]. Acta Phys. -Chim. Sin., 2002,18(01): 70-73
132. Zhou Guo-Ding;Kamkin A N;Liao Qiang-Qiang.Photoelectrochemical Study of Copper-Nickel and Copper-Cobalt Electrodes in Alkaline Solution[J]. Acta Phys. -Chim. Sin., 2001,17(07): 614-618
133. Dai Guo-Liang;Dong Xiang-Qun;Sun Zhi-Wei;Hu Wen-Rui.Study on Lysozyme Crystal Growth by Vapor Diffusion Approach Using Dynamic Light Scattering Method[J]. Acta Phys. -Chim. Sin., 2001,17(06): 531-536
134. Lin Zhong-Yu;Fu Jin-Kun;Wu Jian-Ming;Liu Yue-Ying;Cheng Hu.Preliminary Study on the Mechanism of Nonenzymatic Bioreduction of Precious Metal Ions[J]. Acta Phys. -Chim. Sin., 2001,17(05): 477-480
135. Hou Ruo-Bing;Yi Xiang-Hui;Zeng Rong-Ying;Chen Zhi-Da.Theoretical Studies on the Inhibition of L-lactate Dehydrogenase[J]. Acta Phys. -Chim. Sin., 2001,17(04): 333-337
136. Gao En-Qin;Zhang Li;Yang Mai-Zhi;Cai Sheng-Min.Preparation of TiO2 Nanoparticles by Hydrothermal Method and its Application for Photoelectrochemical Cell[J]. Acta Phys. -Chim. Sin., 2001,17(02): 177-180
137. Kan Jin-Qing;Hou Jun-Hua;Mu Shao-Lin.Bioelectrochemical Characters of Doping-coating Polyanilineuricase Electrode[J]. Acta Phys. -Chim. Sin., 2001,17(01): 32-36
138. Mu Shao-Lin, Yang Yi-Fei.Polyaniline Used as An Electron Transfer Mediator for the Catalyzed Dehydrogenating Renction of Alcohol[J]. Acta Phys. -Chim. Sin., 2000,16(09): 830-834
139. Ge Hong-Hua, Liao Qiang-Qiang, Zhou Guo-Ding.Study of Surface Layer Structure and Corrosion Resistance on Octadecylamine-treated lron[J]. Acta Phys. -Chim. Sin., 2000,16(09): 860-864
140. Yang Hui, Huang Zhi-Zhong, Jiang Hui-Jun, Zhou Jia-Hong, Lu Tian-Hong, Wang Feng-Bin, Xing Wei.Electrocatalytic Reduction of O2 and H2O2 at the Glass Carbon Electrode Modified with Microperoxidase-11[J]. Acta Phys. -Chim. Sin., 2000,16(06): 527-532
141. Hou Ting-Jun, Wu Zeng-Ru, Liao Ning, Li Zheng, Luo Hong-Peng, Hong Jia-Quan, Xu Xiao-Jie.Pharmacophore Model and 3D-QSAR Study of Two Kinds of HCVNS3 Serine Protease Inhibitors[J]. Acta Phys. -Chim. Sin., 2000,16(03): 196-201
142. Miao Wei, Yao Song-Nian.Study of β-1,4-glucosidase in Water/PC/Heptane-Butanol Reverse Micelles[J]. Acta Phys. -Chim. Sin., 1999,15(10): 930-937
143. Li Wei-Hua, Hao Yan-Zhong, Qiao Xue-Bin, Zhang Li, Yang Mai-Zhi, Cai Sheng-Min.Photoelectrochemical Studies on the Nanostructured ZnO/Dye/PPy Electrode[J]. Acta Phys. -Chim. Sin., 1999,15(10): 905-910
144. Sun Ming, Li Wei-Zhong, Yu Ming, Wang Jin-Ling, Miao Fang-Ming, I Basnak, T A Hamor, R T Walker.A Quantum and Docking Study of Substituted Deoxyurdines[J]. Acta Phys. -Chim. Sin., 1999,15(09): 834-837
145. Zhang Li, Gao En-Qin, Yang Mai-Zhi, Qiao Xue-Bin, Hao Yan-Zhong, Cai Sheng-Min, Meng Fan-Shun, Tian He.Photoelectrochemical Properties of the SnO2 Nanoporous Film Sensitized by Cyanine Dye[J]. Acta Phys. -Chim. Sin., 1999,15(04): 293-298
146. Hua Jian-Li, Song Cai-Sheng, Wang Guang-Hui, Cai Ming-Zhong.The application of ESR-spin Stable Technique in Laccase Chemical System[J]. Acta Phys. -Chim. Sin., 1999,15(02): 173-177
147. Wang Ren-Xiao, Liu Liang, Lai Lu-Hua, Tang You-Qi.Structure-Affinity Relationship of Thrombin inhibitors[J]. Acta Phys. -Chim. Sin., 1998,14(10): 887-892
148. Wang Ren-Xiao, Feng Ya-Bin, Lai Lu-Hua, Tang You-Qi.Structure-Affinity Relationship of lndole-Based for Phospholipase A2[J]. Acta Phys. -Chim. Sin., 1998,14(10): 893-897
149. Wang Ren-Xiao, Li Wei-Zhong, Lai Lu-Hua, Tang You-Qi.Estimating Binding Affinities for Enzyme-Ligand Complexes[J]. Acta Phys. -Chim. Sin., 1998,14(09): 826-832
150. Li Wei-Hua, Hao Yan-Zhong, Qiao Xue-Bin, Wang Yan-Qin, Yang Mai-Zhi, Cheng Hu-Min, Cai Sheng-Min.A Photoelectrochemistry Study of the Photosensitization of Composite Sulfides and Ru(II) Complex for TiO2 Nanoporous Film Electrode[J]. Acta Phys. -Chim. Sin., 1998,14(09): 841-845
151. Li Gang, Luo Lai-Bin, Chen Hui-Lan, Fu Shao-Wei, Zhang Shu-Yi.Determination of Enthalpy and Volume Changes in Photolysis of Coenzyme B12 Using Photoacoustic Calorimetry[J]. Acta Phys. -Chim. Sin., 1998,14(07): 615-619
152. Li Wen-Zhong, Miao Fang-Ming.Solvation Interaction and Stability of Modified Superoxide Dismutase[J]. Acta Phys. -Chim. Sin., 1998,14(04): 289-292
153. Liu Min-Sheng,Hao Yan-Zhong,Yu Cheng,Yang Mai-Zhi,Cai Sheng-Min.Photoelectrochemical Studies on the Electrode of Nano-structured TiO2 Porous Film[J]. Acta Phys. -Chim. Sin., 1997,13(11): 992-998
154. Kan Jin-Qing,Mu Shao-Lin.Study on Inhibition of Xanthine Oxidase by Umbelliferone[J]. Acta Phys. -Chim. Sin., 1997,13(07): 650-654
155. Zhao Hai-Yan,Song Shi-Ying,Lin Zheng-Jiong,Du Xiao-Yan,Zhou Yuan-Cong.The Crystallization of Acidic Phospholipase A2 from the Venom of Agkistrodon Blomhoffii Brevicaudus Covalently Inhibited by p-Bromo-phenacyl-bromide[J]. Acta Phys. -Chim. Sin., 1997,13(05): 449-451
156. Fu Shao-Wei,Luo Lai-Bin,Chen Hui-Lan,Wu Zong-Sen,Zhang Shu-Yi.Photoacoustic Investigation of Photolysis of Coenzyme B12[J]. Acta Phys. -Chim. Sin., 1997,13(03): 193-195
157. Kan Jin-Qing,Qiao Yue-Dong,Mu Shao-Lin,Li Yong-Fang.Inhibition of Bioelectrochemical Activities of Polyaniline Uricase Electrode by Theophylline[J]. Acta Phys. -Chim. Sin., 1997,13(03): 236-241
158. Dai Guo-Liang,Li Jun-Ru,Jiang Long.The Effect of LB Technology on Conformation of Glucose Oxidase[J]. Acta Phys. -Chim. Sin., 1997,13(03): 200-203
159. Meng Wu-Yi,Niu Xiu-Tian,Gui Lu-Lu,Lin Zheng-Jiong,Zhu Hong,Zhou Yuan-Cong,Li Gen.Cystallization and Preliminary Diffraction Data of Orthorhombic Crystal Form of Basic Phospholipase A2 from the Venom of Agkistrodon Halys Pallas[J]. Acta Phys. -Chim. Sin., 1996,12(10): 946-949
160. Kou Fu-Ping,Lin Hua-Kuan,Zhu Shou-Rong,Chen Rong-Ti.A Zinc(II) Complex of Tripyridylamine(TPA) as a Model for Carbonic Anhydrase[J]. Acta Phys. -Chim. Sin., 1996,12(09): 804-808
161. Li Xu-Yuan,Zhao Ke-Hao,Meng Yan-fa,Tu Wei-Xia.Purification and Characterization of β-galactosidases from Cicer Arietinum[J]. Acta Phys. -Chim. Sin., 1996,12(07): 629-634
162. Huang Wen,Li Xiao-Feng,Gu Ti-Ren.Conformation and Activity of RNaseA in Dodecylammonium Butyrate-Cyclohexane Reverse Micellar Solution[J]. Acta Phys. -Chim. Sin., 1996,12(04): 353-356
163. Xue Huai-Guo,Zhong Lei,Shao Liang,Kan Jin-Qing,Mu Shao-Lin.Stusy on Inhibition of Xanthine Oxidase by Allopurinol[J]. Acta Phys. -Chim. Sin., 1996,12(04): 310-314
164. Cao Yang,Lu Shou-Yun,Li Ai-Zhen.Photoassisted Microetching of GaSb with Focused Laser Light and the Investigation of its Surface Oxides[J]. Acta Phys. -Chim. Sin., 1996,12(03): 224-228
165. Xia Shi-Wen,Li Shu-Ben,Wei Chi-Li,Shen Run-Nan.Stereoselective Epoxidation of Alkenes Catalyzed by Mycobacterium E3 Resting Cell[J]. Acta Phys. -Chim. Sin., 1996,12(03): 218-223
166. Sun Hong-Mei, Xie Qian, Xie Gui-Ying, Zhou Jia-Ju, Xu Zhi-Hong, Li Zheng-Ming, Jia Guo-Feng, Wang Ling-Xiu.The 3D Biophore Model of Sulfonylurea Herbicides Using APEX-3D Method[J]. Acta Phys. -Chim. Sin., 1995,11(09): 773-776
167. Luo Zhao-Wen,Deng Qiao-Lin,Lai Lu-Hua,Xu Xiao-Jia,Tang You-Qi.Molecular Dynamic Study on Phospholipase A2 and its Complex[J]. Acta Phys. -Chim. Sin., 1995,11(07): 622-626
168. Huang Wen,Li Xiao-Feng,Gu Ti-Ren.Activity of RNaseA in Reverse Micelles Formed by Dodecylammonium Butyrate in Cyclohexane[J]. Acta Phys. -Chim. Sin., 1995,11(07): 579-582
169. Luo Zhao-Wen, Wang Dan-Dan, Lai Lu-Hua, Xu Xiao-Jia, Li Chong-Xi.3D-QSAR Studies of Galanthamine and Analogs[J]. Acta Phys. -Chim. Sin., 1995,11(05): 419-423
170. Zheng Guo-Dong, Yan Yan, Wang Ying, Huang Chu-Bao, Gao De, An Qing-Da.Studies on the Production and Dissociation of Coenzyme B12 Models by Electrochemistry and Spectroelectrochemistry(II)[J]. Acta Phys. -Chim. Sin., 1994,10(09): 831-837
171. Kan Jin-Qing , Mu Shao-Lin.The Effect of O-phenanthroline on the Kinetics of the Immobilized Uricase Catalyzed Reaction[J]. Acta Phys. -Chim. Sin., 1994,10(07): 648-653
172. Pu Zong, Zhou Wei-Fang.Effect of VA Elements on the Semiconducting Properties of the Anodic Plumbous Oxide Flim(II)[J]. Acta Phys. -Chim. Sin., 1994,10(04): 348-353
173. Lv Ming-Xiang, Dai Hong-Li, Zhang Guo-Heng.The Determination of the Second Order Rate Coefficient of Enzymatic Reaction for the Mediator Enzyme Electrode[J]. Acta Phys. -Chim. Sin., 1994,10(04): 354-359
174. Qian Dao-Sun, Zhu Zhen-Hua, Zhao Jun.A Study of Breakdown Process Between n-InP/Solution Interface at Irradiation[J]. Acta Phys. -Chim. Sin., 1994,10(01): 61-63
175. Qian Dao-Sun; Zhu Zhen-Hua; Wang Ping-Chuan.Pulsed Light-induced Transient Behavior at n-InP Electrode in Fe3+/Fe2+(IV)[J]. Acta Phys. -Chim. Sin., 1993,9(06): 791-794
176. Kan Jin-Qing; Mu Shao-Lin.The Study of Properties for the Polyaniline Uricase Electrode[J]. Acta Phys. -Chim. Sin., 1993,9(03): 345-350
177. Wang Wei-Jiang; Wang Jiang-Tao; Jin Cheng-He; Lu Shou-Yun.Photoelectrochemical Microetching of n-GaAs[J]. Acta Phys. -Chim. Sin., 1993,9(03): 386-391
178. Dai Hong-Li; Lv Ming-Xiang.Characteristics of the Response of Enzyme Modified Electrode[J]. Acta Phys. -Chim. Sin., 1993,9(01): 35-40
179. Dong Qing-Hua; Kong Wei-He; Wu Bing-Liang.Photoelectrochemical Studies of Intercalation Reaction[J]. Acta Phys. -Chim. Sin., 1992,8(04): 555-557
180. Qian Dao-Sun; Zhao Jun.Transient Behavior of n-InP/Fe3+, Fe2+ Interface Using Small Current Step[J]. Acta Phys. -Chim. Sin., 1992,8(02): 202-206
181. Chen Yan-Zhen; Xu Ke-Yang; Tian Zhao-Wu.The Stury of Photoelectrochemical Polymerization of Pyrrole on Metal Substractes[J]. Acta Phys. -Chim. Sin., 1991,7(05): 589-592
182. Yang Hua-Quan; Liu Xin; Cai Sheng-Min; Zhou Guo-Ding.A Photoelectrochemical Study of Cyclic Voltammetry of MnO2 Electrode[J]. Acta Phys. -Chim. Sin., 1991,7(04): 409-412
183. Wu Ding-Quan; Mei Fu-Ming; Qu Song-Sheng; Du Yu-Min; Zhan Dong-Feng.Study on the Reaction of Laccase and Hydrogen Peroxide by Microcalorimetry[J]. Acta Phys. -Chim. Sin., 1991,7(04): 490-494
184. Zhang Guo-Dong.Photoelectrochemical Investigation of Passive film on Iron[J]. Acta Phys. -Chim. Sin., 1991,7(03): 366-370
185. Zheng Zhi-Min; Wu Hui-Huang; Zhou Shao-Min.Biofunctional Electrodes III. Study on Electrochemical Immobilization of Glucose Oxidase[J]. Acta Phys. -Chim. Sin., 1991,7(02): 163-168
186. Yang Mai-Zhi; Marc DE Backer.A Study of Photoelectrochemical Properties of Thin Film of Chromium Tetra-2,3-Pyridinoporphyrazine[J]. Acta Phys. -Chim. Sin., 1991,7(02): 238-241
187. Wang Bang-Ning; Tan Fu.Calorimetric Study of the Influence of Hydration and pH Upon the Thermally-Induced Conformational Transition of Proteinase K[J]. Acta Phys. -Chim. Sin., 1991,7(01): 43-48
188. DAI Wei-Guo, HE Dan-Nong.Selective Photoelectrochemical Oxidation of Chiral Ibuprofen Enantiomers[J]. Acta Phys. -Chim. Sin., 0,(): 0-0
189. BAI Guang-Yue, LIU Jun-Ling, WANG Jiu-Xia, WANG Yu-Jie, LI Yan-Na, ZHAO Yang, YAO Mei-Huan.Enzymatic Superactivity and Conformational Change of α-CT Induced by Cationic Gemini Surfactant[J]. Acta Phys. -Chim. Sin., 0,(): 0-0
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