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Acta Phys. -Chim. Sin.  2017, Vol. 33 Issue (5): 1051-1056    DOI: 10.3866/PKU.WHXB201702201
Article     
Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study
LI Hai-Xia1, LIU Yan-Cheng2, TANG Rui-Zhi2, ZHANG Peng2, MA Liu-Kui1, WEI Chi-Yuan1, WANG Wen-Feng2
1 Pujiang Institute, Nanjing Tech University, Nanjing 211132, P. R. China;
2 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China
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Abstract  

The reactions of triplet-state difloxacin (DFX) with various amino acids and deoxyguanylic acid in aqueous media were studied using laser flash photolysis. Tryptophan, tyrosine, cysteine, and 2'-deoxyguanosine-5'-monophosphate (dGMP) were found to completely quench the triplet state of DFX in aqueous solution, the corresponding second-order rate constants being 1.97×108, 1.48×108, 1.72×108, and 6.92×107 dm3·mol-1·s-1. The quenching mechanism involves electron transfer to the photoexcited triplet state of DFX from the tryptophan, tyrosine, cysteine, and dGMP moieties, followed by fast protonation of the resulting DFX anion radical.



Key wordsLaser flash photolysis      Difloxacin      Triplet state      Amino acid     
Received: 18 November 2016      Published: 20 February 2017
MSC2000:  O644  
Fund:  

The project was supported by the National Natural Science Foundation of China (21173252).

Corresponding Authors: WANG Wen-Feng     E-mail: wangwen@sinap.ac.cn
Cite this article:

LI Hai-Xia, LIU Yan-Cheng, TANG Rui-Zhi, ZHANG Peng, MA Liu-Kui, WEI Chi-Yuan, WANG Wen-Feng. Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study. Acta Phys. -Chim. Sin., 2017, 33(5): 1051-1056.

URL:

http://www.whxb.pku.edu.cn/Jwk_wk/wlhx/10.3866/PKU.WHXB201702201     OR     http://www.whxb.pku.edu.cn/Jwk_wk/wlhx/Y2017/V33/I5/1051

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