物理化学学报 >> 1998, Vol. 14 >> Issue (11): 1020-1024.doi: 10.3866/PKU.WHXB19981111

研究论文 上一篇    下一篇

茶多酚类化合物的单电子还原电位

汪朝存, 哈成勇, 姚思德   

  1. 中国科学院广州化学研究所，广州 510650|中国科学院上海原子核研究所，上海 201800
  • 收稿日期:1998-01-04 修回日期:1998-06-11 发布日期:1998-11-15
  • 通讯作者: 汪朝存

One-electron Reduction Potentials of Tea Polyphenolic Compounds

Wang Chao-Cun, Ha Cheng-Yong, Yao Si-De   

  1. Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650|Shanghai Institute of Atom Nuclear,Chinese Academy of Sciences,Shanghai 201800
  • Received:1998-01-04 Revised:1998-06-11 Published:1998-11-15
  • Contact: Wang Chao-Cun

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摘要：

单电子还原电位是辐射保护和敏化中“电荷转移”的根本判据，此文采用时间分辨脉冲电子辐解瞬态吸收光谱装置，在PH＝7.0的磷酸缓冲溶液中，以杜醌（－244mV）为参比，准确地测定了四种茶多酚类衍生物EGCG、GCG、GC、C的单电子还原电位值分别为－316，－325，－328，－326mV；并通过与DNA碱基胸腺嘧啶的单电子还原电位（－1100mV）作比较，从热力学角度初步评价了这类化合物对DNA碱基的辐射损伤均有良好的保护作用．

关键词: 单电子还原电位, 电子亲和势, 辐射保护剂, 脉冲辐解

Abstract:

One-electron reduction potentials could be use as the critical-criteria of charge transfer protect and sensitization. The One-electron reduction potentials of four Tea Polyphenol derivatives using duroquinone as the reference compound have been measured with the technique of pulse radiolysis, the one-electron reduction potentials of EGCG, GCG, GC, C are-316, -325, -328,-326mV, respectively. Acccording to the criteria of charge transfer of protection and sensitization, compared with one-electron reduction potential of thymine (-1100mV), EGCG, GCG, GC and C can be used to protect efficiently the target molecule thymine from the damage induced by electron addition.

Key words: One-elecutron reduction potential, Electron affinity, Radiation protection agent, Pulse radiolysis