Acta Phys. -Chim. Sin. ›› 2008, Vol. 24 ›› Issue (09): 1675-1680.doi: 10.3866/PKU.WHXB20080925

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Effects of Drug Release Mediumon Layered Double Hydroxide Carrier

GOU Guo-Jing; BAO Feng-Juan; XU Hong-Ping; ZHENG Zhi-Xiang   

  1. School of Basic Medical Science , Ningxia Medical College, Yinchuan 750004, P. R. China; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, P. R. China
  • Received:2008-03-03 Revised:2008-04-14 Published:2008-09-10
  • Contact: GOU Guo-Jing

Abstract: Layered double hydroxide (LDH) had been used as a carrier of acetylsalicylic acid (ASP) to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carrier’s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystal-class kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO-4 and hydroxyls of LDH caused laminar carrier transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier’s purity decreased, crystallinity weakened, and micro-pore absorbability declined.

Key words: Drug release medium, LDH-ASP intercalation compound, Crystal change, Controlled-release carrier