Abstract: In this paper, the mechnism of the electrochemical oxidation of vitamin E in acetonitrile and ethanol solvents was studied by cyclic voltammetry, controlled-potential electrolysis coulometry and double potential step chronoamperometry. The oxidation mechanism of vitamin E was suggested by cyclic voltammogram and compared with V. D. Parker′s work for the model compound of vitamin E. Controlledpotential electrolysis coulometry showed that for the oxidition of each molecule of vitamin E two electrons were transferred. The rate constants of the follow-up hydrolysis and ethanolysis reactions of the primary oxidation product were measured and the relative magnitude of this two kinds of follow-up reactions was compared.