Acta Phys. -Chim. Sin. ›› 1998, Vol. 14 ›› Issue (04): 289-292.doi: 10.3866/PKU.WHXB19980401

• Communication •     Next Articles

Solvation Interaction and Stability of Modified Superoxide Dismutase

Li Wen-Zhong, Miao Fang-Ming   

  1. Institute of Chemical Crystallography,Tianjin Normal University,Tianjin 300074 P.R.China|Institute of Physical Chemistry,Peking University,Beijing 100871,P.R.China
  • Received:1997-12-15 Revised:1998-01-07 Published:1998-04-15
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Abstract:

The stability of Copper, Zinc superoxide dismutase increases remarkably when the lysines on the surface of the enzyme are modified. The fmite difference solution to the Poisson-Boltzman equation (FDPB) method is used to calculate the electrostatic interaction between solution and enzyme. The results show that the reaction field energy of SOD is reduced by about,1270kJ•mol-1 after modification.

Key words: Enzyme stability, Finite difference, Superoxide desmutase, Chemical modification, Reaction field energy