竹红菌乙素镁、锌配位聚合物的光物理和光生物性质

doi:10.3866/PKU.WHXB20111132

Abstract

Abstract: Hypocrellin B (HB) can chelate with Mg²⁺ and Zn²⁺ ions to form the coordination complexes Mg²⁺-HB and Zn²⁺-HB, which consist of 5-22 repeat units. The structures of these two complexes are characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and ¹H nuclear magnetic resonance (¹H NMR). The relative quantum yields of singlet oxygen (¹O₂) for Mg²⁺-HB and Zn²⁺-HB are 1.2 and 0.42 times as high as that of HB, respectively. Transient absorption spectra results indicate that O₂ is able to quench the triplet excited state of Mg²⁺-HB and Zn²⁺-HB with an efficiency higher than 96% . The intersystem crossing efficiency (Φ_T) and the fraction of triplet states quenched by O₂ that yield ¹O₂ (f_Δ^T) are considered to be essential for the singlet oxygen quantum yields of HB and its complexes. Electron paramagnetic resonance (EPR) results suggest that Mg²⁺-HB and Zn²⁺-HB have a weak ability to generate a semiquinone anion radical, which reduces the generation of the superoxide anion radical (O₂^·-) by Mg²⁺-HB and Zn²⁺-HB. The results of the UV-Vis spectra and the deoxyribonucleic acid (DNA) melting temperature experiments indicate that Mg²⁺-HB and Zn²⁺-HB bind with calf thymus (CT) DNA in an electrostatic interaction mode. Under aerobic conditions, the efficiencies of photoinduced damage to CT DNA by Mg²⁺-HB, HB, and Zn²⁺-HB are found to be 32%, 25%, and 22%, respectively. The reactive oxygen quencher experiments indicate that singlet oxygen is the main component generated by Mg²⁺-HB that damages CT DNA.

Key words: Hypocrellin B, Coordination polymer, Singlet oxygen, Superoxide anion radical, DNA photodamage

GUO Chuang-Long, OU Zhi-Ze, GAO Yun-Yan, WANG Zhong-Li, JIN He-Lin, LI Hai-Xia. Photophysical and Photobiological Properties of Coordination Polymers of Hypocrellin B Complexes Containing Magnesium and Zinc[J].Acta Phys. -Chim. Sin., 2011, 27(11): 2682-2690.

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Photophysical and Photobiological Properties of Coordination Polymers of Hypocrellin B Complexes Containing Magnesium and Zinc

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