咪唑修饰萘酰亚胺与DNA的作用及其细胞毒性

高云燕,蔡温姣,欧植泽,马拖拖,倚娜,李志远

DNA Interactions and Cytotoxicity of Imidazole-Modified Naphthalimides

Yunyan GAO,Wenjiao CAI,Zhize OU,Tuotuo MA,Na YI,Zhiyuan LI

表1 紫外-可见吸收光谱测定的萘酰亚胺衍生物与双链CT DNA和Htelo G-四链体的结合常数(Kα, L·mol−1)

Table 1 Association constant (Kα, L·mol−1) of naphthalimide derivatives with duplex CT DNA and Htelo G-quadruplex DNA determined by UV-Vis spectroscopy.

Compound CT DNA Htelo DNA Selectivity a Kα Red shift Kα Red shift 3 1.40 × 104 0 7.86 × 106 0 561 4a 5.31 × 104 0 4.27 × 106 0 80.2 4b 4.65 × 104 3 1.41 × 107 3 301 4c 1.24 × 105 10 9.22 × 106 4 74.4