咪唑修饰萘酰亚胺与DNA的作用及其细胞毒性

高云燕,蔡温姣,欧植泽,马拖拖,倚娜,李志远

DNA Interactions and Cytotoxicity of Imidazole-Modified Naphthalimides

Yunyan GAO,Wenjiao CAI,Zhize OU,Tuotuo MA,Na YI,Zhiyuan LI

表3 萘酰亚胺衍生物对A549和MRC-5细胞的细胞毒性

Table 3 Data for the cytotoxicity (IC50, μmol·L−1) of naphthalimides against A549 and MRC-5 cells.

Compound A549 MRC-5 MRC-5IC50/A549IC50 3 15.3 ± 1.30 19.8 ± 2.1 1.29 4a 2.64 ± 0.42 7.93 ± 0.21 3.04 4b 2.23 ± 0.39 7.06 ± 0.89 3.16 4c 3.34 ± 0.53 3.63 ± 0.58 1.08 Mitonafide 3.78 ± 0.31 1.81 ± 0.15 0.47