咪唑修饰萘酰亚胺与DNA的作用及其细胞毒性

高云燕,蔡温姣,欧植泽,马拖拖,倚娜,李志远

DNA Interactions and Cytotoxicity of Imidazole-Modified Naphthalimides

Yunyan GAO,Wenjiao CAI,Zhize OU,Tuotuo MA,Na YI,Zhiyuan LI

图7 化合物3 (a，b)，4a(c，d)和4c (e，f)与端粒G-四链体DNA (PDB ID: 1KF1)对接作用的模式图。红色虚线表示化合物与G-四链体间的氢键或静电作用

Fig 7 Different views of the docked model of 3 (a, b), 4a (c, d) and 4c (e, f) with telomeric G-quadruplex DNA (PDB ID: 1KF1). The red dashed lines represent the hydrogen bonding or electrostatic interaction between naphthalimides and G-quadruplex.