Acta Phys. -Chim. Sin. ›› 2001, Vol. 17 ›› Issue (10): 879-886.doi: 10.3866/PKU.WHXB20011004

• ARTICLE • Previous Articles     Next Articles

Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds

Xu Si-Chuan;Zhang Hui-Juan;Sun Zhao-Yong;Feng Juan;Ai Xi-Cheng;Zhang Qi-Yuan;Zhang Xing-Kang;Liu Yan-Qin;Han Shi-Tian   

  1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing　100080;Department of Chemistry, Hebei Normal University, Shijiazhuang　050091
  • Received:2001-04-16 Revised:2001-05-17 Published:2001-10-15
  • Contact: Xu Si-Chuan E-mail:xusc@chem.pku.edu.cn

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Abstract: 5fluorouracil porphyrin compounds are a new type of potential antitumor drugs. Six new 5fluorouracil porphyrin compounds were synthesized first and characterized by means of elemental analysis, IR, 1HNMR and MS. The six 5fluorouracil porphyrin compounds were studied by absorption spectra, steadystate fluorescence spectroscopy and timeresolved single photon measurement, comparing with their primary porphyrin compounds. The 5fluorouracil porphyrin compounds with plentiful excited states and fluorescence lifetime of 7 ns are little influenced by substituents and solvents, which may be advantageously used to make singlet oxygen radical.

Key words: 5-fluorouracil, Porphyrin, Fluorescence lifetime, Single photon measurement