蛋白质-RNA相互作用界面预测与设计

doi:10.3866/PKU.WHXB201209111

Abstract

Abstract:

RNA-protein interactions play key roles in many biological processes. The three dimensional (3D) structure of protein-RNA complexes can be determined experimentally by structural biologists. The recognition between protein and RNA can be understood from the 3D atomic structure. However, the structure determination of protein-RNA complexes by experimental methods is often difficult and costly, and limited to the binding strength. Thus, the prediction and design of protein-RNA complex structures is important in biological medical research. In this review, we will discuss the recent progress in protein-RNA interface prediction and design, which includes the following aspects: (1) protein-RNA docking and the conformational change on binding; (2) the recognition mechanism of protein-RNA binding; (3) the molecular design based on the protein-RNA interface. Improvement of the protein-RNA docking algorithm will help us annotate a large number of proteins and RNA with unknown function, and molecular design based on macromolecular interactions will be useful in drug design.

Key words: Protein-RNA interaction, Molecular docking, Interface design, Complex structure prediction

HUANG Yang-Yu, YANG Xiu-Feng, LI Hao-Tian, JI Xiao-Feng, CHENG Hong-Li, ZHAO Yun-Jie, GUO Da-Chuan, LI Lin, LIU Shi-Yong. Protein-RNA Interaction Interface Prediction and Design[J]. Acta Phys. -Chim. Sin. 2012, 28(10), 2390-2400. doi: 10.3866/PKU.WHXB201209111

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Protein-RNA Interaction Interface Prediction and Design

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