Acta Phys. -Chim. Sin. ›› 2017, Vol. 33 ›› Issue (4): 823-828.doi: 10.3866/PKU.WHXB201701092

• ARTICLE • Previous Articles     Next Articles

Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies

Tian-Yi JI1,2,Yan-Cheng LIU2,Jian-Feng ZHAO2,3,Gang XU1,Wen-Feng WANG2,*(),Ming-Hong WU1,*()   

  1. 1 School of Environment and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China
    2 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China
    3 University of Chinese Academy of Sciences, Beijing 100049, P. R. China
  • Received:2016-11-08 Published:2017-03-23
  • Contact: Wen-Feng WANG,Ming-Hong WU;
  • Supported by:
    National Natural Science Foundation of China(21173252);National Natural Science Foundation of China(41430644);National Natural Science Foundation of China(11675098)


The reactions of the pharmaceutical fluoxetine (FLX) with different radicals were investigated by pulse radiolysis. The reaction of hydroxyl radical (·OH) with FLX formed hydroxylated adduct of the aromatic ring, while oxidation of FLX by sulfate radical anion (SO4·-) formed benzene radical cation that further reacted with H2O to yield the ·OH adduct. The determined rate constants of ·OH, hydrated electrons (eaq-), and SO4·- with FLX were 7.8×109, 2.3×109, and 1.1×109 mol·L-1·s-1, respectively. In the steady-state radiolysis study, the degradation of FLX in different radiolytic conditions by electron beam irradiation was detected by HPLC and UV-Vis spectra techniques. It was found that FLX concentration decreased by more than 90% in both N2O and air-saturated solutions after 1.5 kGy irradiation. In contrast, only 43% of FLX was decomposed in N2-saturated solution containing 0.1 mol·L-1 tert-butanol. The degradation rates of FLX in acidic and neutral solutions were higher than those in alkaline solutions. Our results showed that the degradation of FLX is optimal in air-saturated neutral solution, and ·OH-induced degradation is more efficient than SO4·- oxidation of FLX. The obtained kinetic data and optimal conditions give some hints to understand the degradation of FLX.

Key words: Fluoxetine, Pulse radiolysis, Hydroxyl radical, Sulfate radical anion, Degradation