自由基诱导的水溶液中氟西汀的降解:脉冲辐解及稳态辐照研究

doi:10.3866/PKU.WHXB201701092

Abstract

Abstract:

The reactions of the pharmaceutical fluoxetine (FLX) with different radicals were investigated by pulse radiolysis. The reaction of hydroxyl radical (·OH) with FLX formed hydroxylated adduct of the aromatic ring, while oxidation of FLX by sulfate radical anion (SO₄^·-) formed benzene radical cation that further reacted with H₂O to yield the ·OH adduct. The determined rate constants of ·OH, hydrated electrons (e_aq^-), and SO₄^·- with FLX were 7.8×10⁹, 2.3×10⁹, and 1.1×10⁹ mol·L^-1·s^-1, respectively. In the steady-state radiolysis study, the degradation of FLX in different radiolytic conditions by electron beam irradiation was detected by HPLC and UV-Vis spectra techniques. It was found that FLX concentration decreased by more than 90% in both N₂O and air-saturated solutions after 1.5 kGy irradiation. In contrast, only 43% of FLX was decomposed in N₂-saturated solution containing 0.1 mol·L^-1 tert-butanol. The degradation rates of FLX in acidic and neutral solutions were higher than those in alkaline solutions. Our results showed that the degradation of FLX is optimal in air-saturated neutral solution, and ·OH-induced degradation is more efficient than SO₄^·- oxidation of FLX. The obtained kinetic data and optimal conditions give some hints to understand the degradation of FLX.

Key words: Fluoxetine, Pulse radiolysis, Hydroxyl radical, Sulfate radical anion, Degradation

Tian-Yi JI,Yan-Cheng LIU,Jian-Feng ZHAO,Gang XU,Wen-Feng WANG,Ming-Hong WU. Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies[J]. Acta Phys. -Chim. Sin. 2017, 33(4), 823-828. doi: 10.3866/PKU.WHXB201701092

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Radical-Induced Degradation of Fluoxetine in Aqueous Solution by Pulse and Steady-State Radiolysis Studies

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