Acta Phys. -Chim. Sin. ›› 2003, Vol. 19 ›› Issue (02): 134-138.doi: 10.3866/PKU.WHXB20030209

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Microcalorimetric Study of the Action of Two Kinds of Lanthanide Monoporphyrinate Complexes on Growth Metabolism of Escherichia Coli

Hou An-Xin;Qu Song-Sheng;Wong Wai-Kwok;Liu Yi   

  1. Department of Chemistry, College of Chemistry and Molecular Science, Wuhan University, Wuhan　430072；Department of Chemistry, Hong Kong Baptist University, Hong Kong
  • Received:2002-06-14 Revised:2002-08-30 Published:2003-02-15
  • Contact: Liu Yi E-mail:liuyi@chem.whu.edu.cn

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Abstract: The biothermochemical characteristics of the actions of two kinds of cationic lanthanide(III) monoporphyrinate complexes {[Re(TMP)(H2O)3]Cl, Re=Y, Yb, TMP=5,10,15,20 -tetrakis(4’-methoxyphenyl)porphyrin} on growth metabolism of Escherichia coli were studied by means of a LKB-2277 bioactivity monitor at 37 ℃.The maximum power, Pmax; the growth rate constant k1,k2; inhibitive ratio I(％) and half inhibition concentration cI,50 (mg•L-1),respectively, were obtained. Experimental results show that porphyrinate complexes possess the bi-directional biological effection: they stimulate the growth of the E. coli at lower concentration but inhibit the growth at higher concentration. Inhibitory effection of [Yb(TMP)(H2O)3]Cl (cI,50=143 mg•L-1) is stronger than that of [Y(TMP)(H2O)3]Cl.

Key words: Cationic lanthanide(III) monoporphyrinate complexes, 　　Microcalorimetriy, Escherichia coli(E.coli), Bi-directional effection, 　Thermokinetic parameters