Acta Phys. -Chim. Sin. ›› 2015, Vol. 31 ›› Issue (7): 1359-1364.doi: 10.3866/PKU.WHXB201504131

• SOFT MATTER • Previous Articles     Next Articles

Influence of Alkyl Polyglucoside on Migration and Extension of pH Window for Forming Fatty Acid Vesicles of Conjugated Linoleic Acid

MA Jie, FAN Ye, FANG Yun   

  1. Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu Province, P. R. China
  • Received:2015-02-09 Revised:2015-04-13 Published:2015-07-08
  • Contact: FANG Yun
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21276113).


Fatty acid vesicles (FAVs) have hollow core-shell structures similar to those of liposomes, and the building block fatty acids are naturally abundant, green, and safe; therefore, FAVs have potential applications in embedding/release systems. However, FAVs are pH sensitive, and the pH window for FAV formation is narrow and biologically unsuitable. These disadvantages prevent FAVs from being used in domestic chemicals and externally applied agents. In this study, a green and safe nonionic surfactant, alkyl polyglucoside (APG), was blended with a model fatty acid conjugated linoleic acid (CLA) to help the latter to form FAVs in a biologically suitable pH window. The experimental results showed that mixing CLA with APG changed the pH window from 8.0-9.0 for CLA to 6.0-8.0 for CLA-APG; this matches the biologically suitable pH range. Methods for improving the pH dependence of FAV formation and the pH-sensitive properties of FAVs were investigated.

Key words: Fatty acid vesicle, pH window, Conjugated linoleic acid, Alkyl polyglucoside