物理化学学报 >> 2006, Vol. 22 >> Issue (09): 1159-1162.doi: 10.3866/PKU.WHXB20060925

研究简报 上一篇    下一篇

D-、L-和DL-青霉胺的太赫兹时域光谱

吉特;赵红卫;张增艳;葛敏;王文锋;余笑寒;徐洪杰   

  1. 中国科学院上海应用物理研究所, 上海 201800
  • 收稿日期:2006-02-14 修回日期:2006-05-26 发布日期:2006-09-04
  • 通讯作者: 余笑寒 E-mail:yuxh@sinap.ac.cn

Terahertz Time-Domain Spectroscopy of D-, L-, and DL- Penicillamines

JI Te;ZHAO Hong-Wei;ZHANG Zeng-Yan;GE Min;WANG Wen-Feng;YU Xiao-Han;XU Hong-Jie   

  1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China
  • Received:2006-02-14 Revised:2006-05-26 Published:2006-09-04
  • Contact: YU Xiao-Han E-mail:yuxh@sinap.ac.cn

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摘要： 利用太赫兹时域光谱技术(THz-TDS)对D-、L-和DL-青霉胺的研究发现, 三种样品在0.2 THz到1.8 THz波段的吸收光谱存在显著差异, 实验结果表明, THz吸收光谱能够鉴别青霉胺对映异构体, 这一特点将可以用于青霉胺药物的检测. 本文利用纯D-、L-青霉胺的THz吸收光谱, 对D-、L-青霉胺混合样品的THz吸收光谱进行拟合, 证明可以用THz光谱定量分析混合样品中D-、L-青霉胺的相对含量. 这项研究为手性药物分子检测和分析提供了新的实验方法, 也对深入了解手性药物与生物靶分子之间相互作用提供了启示.

关键词: 太赫兹时域光谱, D-、L-、DL-青霉胺, 对映异构体, 定量分析

Abstract: Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.

Key words: THz-TDS, D-, L-, and DL- penicillamines, Enantiomers, Quantitative analysis