物理化学学报 >> 2007, Vol. 23 >> Issue (09): 1459-1462.doi: 10.3866/PKU.WHXB20070929

研究简报 上一篇    下一篇

丙硫异烟胺的热稳定性及其热分解动力学

王韶旭; 赵哲; 谭志诚; 李彦生; 童波; 史全; 李英   

  1. 大连交通大学环境与化学工程学院, 辽宁 大连 116028; 中国科学院大连化学物理研究所材料热化学实验室, 辽宁 大连 116023
  • 收稿日期:2007-03-27 修回日期:2007-06-05 发布日期:2007-09-06
  • 通讯作者: 谭志诚 E-mail:tzc@dicp.ac.cn

Thermal Stability and Kinetics of Thermal Decomposition for Protionamide

WANG Shao-Xu; ZHAO Zhe; TAN Zhi-Cheng; LI Yan-Sheng; TONG Bo; SHI Quan; LI Ying   

  1. College of Environmental Science &Chemical Engineering, Dalian Jiaotong University, Dalian 116028, Liaoning Province, P. R. China; Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning Province, P. R. China
  • Received:2007-03-27 Revised:2007-06-05 Published:2007-09-06
  • Contact: TAN Zhi-Cheng E-mail:tzc@dicp.ac.cn

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摘要： 通过热重法研究了抗结核药物丙硫异烟胺的热稳定性, 计算了该药物的动力学参数并建立了热分解动力学方程. 用Kissinger和Ozawa-Flynn-Wall两种方法计算该药物热分解过程的活化能Ea=54.65 kJ·mol-1. 用Malek法推断该药物的动力学机理函数及指前因子A, 其结果分别为f(α)=α0.391(1-α)0.145, lnA=13.12. 此外, 用差热法测定该物质的熔点、摩尔熔化焓和摩尔熔化熵, 分别是414.09 K、23.21 kJ·mol-1和56.06 J·mol-1·K-1.

关键词: 丙硫异烟胺； 热分解动力学； 热重分析； 差热分析； 热力学性质

Abstract: The thermal stability and the kinetics of thermal decomposition of protionamide were studied by thermogravimetry. Activation energy Ea of thermal decomposition of this substance was obtained to be 54.65 kJ·mol-1 by Kissinger method and Ozawa-Flynn-Wall method. Kinetics model function and frequency factor A of protionamide were predicted with the Malek method, which were f(α)=α0.391(1-α)0.145 and lnA=13.12, respectively. Moreover, melting point, molar enthalpy and entropy of fusion of this compound were determined to be 414.09 K, 23.21 kJ·mol-1, and
56.06 J·mol-1·K-1, respectively.

Key words: Protionamide, Kinetics of thermal decomposition, Thermogravimetry, Differential thermal analysis, Thermodynamic property