物理化学学报 >> 2008, Vol. 24 >> Issue (09): 1675-1680.doi: 10.3866/PKU.WHXB20080925

研究论文 上一篇    下一篇

药物释放环境对层状复合氢氧化物载体的影响

苟国敬; 鲍凤娟; 许红平; 郑志详   

  1. 宁夏医学院基础学院, 银川 750004; 宁夏大学化学化工学院, 银川 750021
  • 收稿日期:2008-03-03 修回日期:2008-04-14 发布日期:2008-09-10
  • 通讯作者: 苟国敬 E-mail:ggj64@yahoo.com.cn

Effects of Drug Release Mediumon Layered Double Hydroxide Carrier

GOU Guo-Jing; BAO Feng-Juan; XU Hong-Ping; ZHENG Zhi-Xiang   

  1. School of Basic Medical Science , Ningxia Medical College, Yinchuan 750004, P. R. China; College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, P. R. China
  • Received:2008-03-03 Revised:2008-04-14 Published:2008-09-10
  • Contact: GOU Guo-Jing E-mail:ggj64@yahoo.com.cn

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摘要： 以层状复合氢氧化物(LDH)为载体用离子交换法制取乙酰苯甲酸(ASP)的插层复合物LDH-ASP, 通过体外释放实验和固相XRD、FT-IR、TEM、TG-DSC及BET-N2比表面积表征, 研究了药物释放环境对载体结构的影响. 结果表明释放环境pH为4.30-6.89时, 载体的层状特征减弱但晶体类型不变; pH为2.48-4.30时, H2PO-4对LDH的嫁接反应引起层状化合物向复杂磷酸盐转化; 随环境pH由6.89降低至2.48, 载体纯度下降, 晶态性征减弱,微孔吸附活性降低.

关键词: 药物释放环境, LDH-ASP复合物, 晶型转化, 控释载体

Abstract: Layered double hydroxide (LDH) had been used as a carrier of acetylsalicylic acid (ASP) to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carrier’s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystal-class kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO-4 and hydroxyls of LDH caused laminar carrier transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier’s purity decreased, crystallinity weakened, and micro-pore absorbability declined.

Key words: Drug release medium, LDH-ASP intercalation compound, Crystal change, Controlled-release carrier