物理化学学报 >> 2009, Vol. 25 >> Issue (03): 502-506.doi: 10.3866/PKU.WHXB20090317

研究论文 上一篇    下一篇

胆酸和L-苯丙氨酸的固相包合作用

刘世香 方春英 郎哲思 戴星 王兴峰 杨运旭   

  1. 北京科技大学化学系, 北京 100083
  • 收稿日期:2008-08-27 修回日期:2008-12-19 发布日期:2009-03-02
  • 通讯作者: 杨运旭 E-mail:yxyang63@yahoo.com.cn

Solid-State Complexation of Cholic Acid and L-Phenylalanine

LIU Shi-Xiang, FANG Chun-Ying, LANG Zhe-Si, DAI Xing, WANG Xing-Feng, YANG Yun-Xu   

  1. Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, P. R. China
  • Received:2008-08-27 Revised:2008-12-19 Published:2009-03-02
  • Contact: YANG Yun-Xu E-mail:yxyang63@yahoo.com.cn

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摘要：

研究了胆酸(CA)和L-苯丙氨酸(PAA)以固相熔融法形成的固相包埋配位. 通过粉末X射线衍射图、红外光谱、粉末荧光光谱及差热分析方法, 测定了固相包埋形成的CA-PAA配合物. 同时, 用溶剂共沉淀法和机械研磨法对比了CA-PAA包埋物的形成. 结果表明, 封管固相熔融时PPA以客体形式被包合进主体CA形成的通道; 研磨法中CA部分包埋PPA; 溶剂共沉淀方法中, PPA不被主体CA包埋, 而使用的相应溶剂被CA包埋.

关键词: 胆酸, L-苯丙氨酸, 固相, 包合

Abstract:

Solid-state complexation of cholic acid (CA)/L-phenylalanine (PAA) using a sealed-heating method was investigated. Powder X-ray diffractometry, IR spectroscopy, powder fluorescence spectroscopy, and differential thermal analysis (DTA) were used to characterize the CA-PAAcomplex. The result showed that PAA, as a guest, was assumed to be included in the channel of the complex formed by CA. While, grinding and co-precipitation methods were also compared to the sealed-heating method for the formation of the CA-PAA complex. It was shown that parts of the PAA were included into the channel of the CA complex during grinding and some solvents were also preferentially included into the guest compounds, which formed a stable cholic acid-solvent complex when co-precipitation method was used.

Key words: Cholic acid, L-Phenylalanine, Solid-state, Complexation