物理化学学报 >> 1987, Vol. 3 >> Issue (06): 638-641.doi: 10.3866/PKU.WHXB19870615

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酪氨酸铜催化抗坏血酸有氧氧化动力学研究

鲁纯素; 杨昭鹏   

  1. 北京医科大学药学院 中国医学科学院, 北京
  • 收稿日期:1986-03-18 修回日期:1987-08-13 发布日期:1987-12-15

KINETICS OF ASCORBIC ACID OXIDATION CATALYSED BY Cu (Ⅱ)-TYROSINE COMPLEX

Lu Chunsu; Yang Zhaopeng   

  1. School of Pharmaceutical Sciences, Beijing Medical University
    Chinese Academy of Medical Sciences, Beijing
  • Received:1986-03-18 Revised:1987-08-13 Published:1987-12-15

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Abstract: The kinetics of L-ascorbic acid (H_2A) oxidation catalysed by Cu(Ⅱ) -Tyrosine complex has been studied in phosphate buffer (pH=7.44) at room temperature. The rate of Cu(Ⅱ)-Tyr_2 catalysed reaction comformed to the Michalies-Menten equation with respect to ascorbate (K_m=4.29×10~(-4) mol L~(-1); v_(max)=1.66×10~(-4) mol min~(-1)). H_2O_2 and O_2~- were produced during this reaction. The rates were decreased due to add the CAT or SOD respectively, A mechanism has been proposed.