物理化学学报 >> 2003, Vol. 19 >> Issue (04): 368-371.doi: 10.3866/PKU.WHXB20030419

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凝胶体系中不同结构羧酸盐对草酸钙生物矿化的影响

欧阳健明;谭燕华;沈玉华   

  1. 暨南大学生物矿化与结石病防治研究所，广州　510632；安徽大学化学化工学院，合肥　230039
  • 收稿日期:2002-07-17 修回日期:2002-10-17 发布日期:2003-04-15
  • 通讯作者: 欧阳健明 E-mail:toyjm@jnu.edu.cn

Effect of Structurally-Specific Carboxylates on Biomineralization of Calcium Oxalate in Gel Systems

Ouyang Jian-Ming;Tan Yan-Hua;Shen Yu-Hua   

  1. Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou　510632; College of Chemistry and Chemical Engineering, Anhui University, Hefei　230039
  • Received:2002-07-17 Revised:2002-10-17 Published:2003-04-15
  • Contact: Ouyang Jian-Ming E-mail:toyjm@jnu.edu.cn

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摘要： 采用双扩散法研究了凝胶体系中四元羧酸盐(Na2EDTA)、三元羧酸盐柠檬酸钠（Na3cit）、二元羧酸盐酒石酸钠（Na2tart）和一元羧酸盐醋酸钠（NaAc）对草酸钙（CaOx）结晶的影响.抑制一水草酸钙（COM）聚集的能力为:Na2EDTA >Na3cit >Na2tart >NaAc；诱导二水草酸钙（COD）的能力为：Na3cit >Na2tart >Na2EDTA >NaAc.羧酸的抗衡阳离子影响CaOx的结晶. H3cit、Na3cit和K3cit抑制COM聚集和诱导COD形成的能力均为:K3cit-Na3cit >H3cit.无论是诱导COD生成，还是抑制COM聚集，均可以减小结石形成的几率，对临床上防治结石具有积极的意义.

关键词: 草酸钙, 尿路结石, 羧酸盐, 凝胶

Abstract: The effects of structurally-specific carboxylates on the crystallization of calcium oxalate(CaOx) were investigated in gel by a double diffusion technique. The ability to inhibit the aggregation of calcium oxalate monohydrate (COM) follows the sequence: tetracarboxylate (Na2EDTA) >tricarboxylate (sodium citrate) > dicarboxylate (sodium tartrate) >monocarboxylate (NaAc). The ability to induce calcium oxalate dihydrate (COD) follows the order: sodium citrate >sodium tartrate >Na2EDTA >NaAc. The counterions of carboxylic acids affected the crystallization of CaOx. The ability of both inhibiting the aggregation of COM and inducing the formation of COD follows the sequence: potassium citrate >> sodium citrate >citric acid. Both inhibiting the aggregation of COM and inducing the formation of COD can decrease the probability of the formation of urinary stones. These results may have positive significance in the prevention and cure of urinary stones.

Key words: Calcium oxalate, Urinary stone, Carboxylate, Gel