物理化学学报 >> 2004, Vol. 20 >> Issue (10): 1196-1199.doi: 10.3866/PKU.WHXB20041006

研究论文 上一篇    下一篇

H＋对水溶液中脱氧胆酸钠聚集体的影响

张莉;杨展澜;熊尧;彭疼疼;翁诗甫;吴瑾光   

  1. 北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京　100871
  • 收稿日期:2004-02-10 修回日期:2004-05-20 发布日期:2004-10-15
  • 通讯作者: 吴瑾光 E-mail:wjg@chem.pku.edu.cn

Influence of H＋ on the Aggregation Properties of Sodium Deoxycholate Aqueous Solution

Zhang Li;Yang Zhan-Lan;Xiong Yao;Peng Teng-Teng;Weng Shi-Fu;Wu Jin-Guang   

  1. State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing　100871
  • Received:2004-02-10 Revised:2004-05-20 Published:2004-10-15
  • Contact: Wu Jin-Guang E-mail:wjg@chem.pku.edu.cn

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摘要： 运用pH滴定、傅立叶变换红外光谱、紫外可见光谱、激光光散射谱、ICP和元素分析等方法研究了H＋的加入对水溶液中脱氧胆酸钠（NaDC）聚集体的影响.结果表明,浓度大于cmc的NaDC水溶液具有一定的缓冲能力,NaDC浓度越高,缓冲能力越大;随溶液中H＋浓度的增加,首先形成质子化胶团,质子化胶团通过酸盐结构的氢键作用使NaDC初级胶团长大,形成较大的高级胶团,甚至形成凝胶体,最终形成HnNam(DC)n＋m沉淀.

关键词: 脱氧胆酸钠, pH滴定, 胶团, 氢键作用

Abstract: The pH of bile is 6～8 in human gallbladder. The changes in pH will probably effect bile composition, which is important for gallstone formation. But little attention has been given to the influence of H＋ on bile salts aggregates in aqueous solution. Our work focused on the changes of NaDC aggregates with adding H＋ by using pH titration, FT-IR, UV-Vis and QELS (quasi-elastic light-scattering spectrometer) spectroscopies. The following conclusions are given: (1) With addition of H＋ into NaDC aqueous solution above the cmc, The aggregation of NaDC micellar changes gradually into protonated micellar aggregates, secondary or mixed aggregates, and eventually gel-like precipitates.(2) The strong H-bond with the acid salt mode induces protonated micellar aggregation to connect with primary micelles of NaDC. (3) Therefore, aqueous micellar NaDC has a buffering capacity and can increase the solubility of HDC.

Key words: Sodium deoxycholate, pH titration, Micelle, H-bond influence