HA/PDM自组装复合胶体粒子及其乳化性能

doi:10.3866/PKU.WHXB201302271

Abstract

Abstract:

The anionic biomacromolecule, hyaluronic acid (HA), and cationic monomer, 2-(dimethylamino) ethyl methacrylate (DM), were used to construct an opposing charge polymer/monomer complex. Positively charged poly[2-(dimethylamino)ethyl methacrylate] (PDM) was prepared when DM monomers polymerized in aqueous solution. Self-assembly between PDM and HA was driven by electrostatic interaction, and HA/PDM complex colloid particles were formed in the aqueous medium. The HA/PDM complex structure was characterized by Fourier transform-infrared (FTIR) spectroscopy. The self-assembly behavior between HA and PDM, and the influence of polymerization time on HA/PDM complex colloid particle size, were investigated by dynamic laser scattering (DLS). Morphologies of the colloid particles were characterized by transmission electron microscopy (TEM). The influence of pH on the size and zeta potential of the colloid particles was investigated, and the emulsification of the colloid particles was preliminarily explored. The results showed that no HA/DM complex aggregates were formed before the polymerization of DM monomers. Spherical HA/PDM particles were spontaneously formed through electrostatic interaction between HA and PDM, coinciding with the gradual polymerization of DM. Particle sizes gradually decreased and stabilized with increasing polymerization time. The HA/PDM particles were pH sensitive and possessed improved emulsification properties compared with uncomplexed HA and PDM.

Key words: Hyaluronic acid, Poly[2-(dimethylamino)ethyl methacrylate], Electrostatic interaction, Self-assembly, Colloid particle, Emulsification

WANG Juan-Qin, BAI Hui-Yu, YI Cheng-Lin, LIU Na, LIU Xiao-Ya. Self-Assembled HA/PDM Particles and Emulsification Properties[J]. Acta Phys. -Chim. Sin. 2013, 29(05), 1028-1034. doi: 10.3866/PKU.WHXB201302271

References

(1) Kötz, J.; Kosmella, S.; Beitz, T. Prog. Polym. Sci. 2001, 26 (8),1199. doi: 10.1016/S0079-6700(01)00016-8
(2) Zintchenko, A.; Dautzenberg, H.; Tauer, K.; Khrenov, V.Langmuir 2002, 18 (4), 1386. doi: 10.1021/la011267u
(3) Dautzenberg, H. Macromolecules 1997, 30 (25), 7810.doi: 10.1021/ma970803f
(4) Kamimura, M.; Kim, J. O.; Kabanov, A. V.; Bronich, T. K.;Nagasaki, Y. J. Control. Release 2012, 160 (3), 486. doi: 10.1016/j.jconrel.2012.04.027
(5) Harada, A.; Kataoka, K. Science 1999, 283 (5398), 65. doi: 10.1126/science.283.5398.65
(6) Cheng, Z. Y.; Ren, B. Y.; Gao, M.; Liu, X. X.; Tong, Z.Macromolecules 2007, 40 (21), 7638. doi: 10.1021/ma071072e
(7) Liu, Z. H.; Shang, Y. Z.; Huang, Y. M.; Peng, C. J.; Liu, H. L.Acta Phys. -Chim. Sin. 2011, 27 (5), 1135. [刘振海, 尚亚卓,黄永民, 彭昌军, 刘洪来. 物理化学学报, 2011, 27 (5), 1135.]doi: 10.3866/PKU.WHXB20110406
(8) Morfin, I.; Buhler, E.; Cousin, F.; Grillo, I.; Boué, F.Biomacromolecules 2011, 12 (4), 859. doi: 10.1021/bm100861g
(9) De la Fuente, M.; Seijo, B.; Alonso, M. J. Macromol. Biosci.2008, 8 (5), 441.
(10) Cai, H.; Ni, C. H.; Zhang, L. P. Eur. J. Pharm. Sci. 2012, 45 (1-2), 43. doi: 10.1016/j.ejps.2011.10.020
(11) Yang, J. S.; Chen, S. B.; Fang, Y. Carbohyd. Polym. 2009, 75 (2), 333. doi: 10.1016/j.carbpol.2008.07.037
(12) Boddohi, S.; Moore, N.; Johnson, P. A.; Kipper, M. J.Biomacromolecules 2009, 10 (6), 1402. doi: 10.1021/bm801513e
(13) Hu, Y.; Jiang, X. Q.; Ding, Y.; Chen, Q.; Yang, C. Z. Adv. Mater.2004, 16 (11), 934.
(14) Ding, Y.; Chen, Q.; Qian, H. Q.; Chen, Y.;Wu,W.; Hu, Y.;Jiang, X. Q. Macromol. Biosci. 2009, 9 (12), 1272. doi: 10.1002/mabi.v9:12
(15) Hu, Y.; Chen, Y.; Chen, Q.; Zhang, L. Y.; Jiang, X. Q.; Yang, C.Z. Polymer 2005, 46 (26), 12703. doi: 10.1016/j.polymer.2005.10.110
(16) Guo, R.; Zhang, L. Y.; Jiang, Z. P.; Cao, Y.; Ding, Y.; Jiang, X.Q. Biomacromolecules 2007, 8 (3), 843. doi: 10.1021/bm060906i
(17) Gatej, I.; Popa, M.; Rinaudo, M. Biomacromolecules 2005, 6 (1), 61. doi: 10.1021/bm040050m
(18) Lee, H.; Lee, K.; Park, T. G. Bioconjugate Chem. 2008, 19 (6),1319. doi: 10.1021/bc8000485
(19) Tanaka, N.; Yoshiike, Y.; Yoshiyama, C.; Kitaoka, T. Carbohyd.Polym. 2010, 82 (1), 100. doi: 10.1016/j.carbpol.2010.04.028
(20) Xu, J.; Ai, L.; Bai, H. Y.; Jiang, J. Q.; Xia,W. S.; Liu, X. Y.Polymer Bulletin 2011, No. 2, 78. [徐晶, 艾玲, 白绘宇,江金强, 夏文水, 刘晓亚. 高分子通报, 2011, No. 2, 78.]
(21) Lenormand, H.; Deschrevel, B.; Vincent, J. Carbohyd. Polym.2010, 82 (3), 887. doi: 10.1016/j.carbpol.2010.06.011
(22) Xu, J.; Bai, H. Y.; Yi, C. L.; Luo, J.; Yang, C.; Xia,W. S.; Liu,X. Y. Carbohyd. Polym. 2011, 86 (2), 678. doi: 10.1016/j.carbpol.2011.05.006
(23) Tao, Y. H.; Xu, J.; Chen, M. Q.; Bai, H. Y.; Liu, X. Y. Carbohyd.Polym. 2012, 88 (1), 118. doi: 10.1016/j.carbpol.2011.11.075
(24) Tan, Y.; Xu, K.; Liu, C.; Li, Y.; Lu, C.;Wang, P. Carbohyd.Polym. 2012, 88 (4), 1358. doi: 10.1016/j.carbpol.2012.02.018
(25) Yusoff, A.; Murray, B. S. Food Hydrocolloids 2011, 25 (1), 42.doi: 10.1016/j.foodhyd.2010.05.004
(26) Gharsallaoui, A.; Yamauchi, K.; Chambin, O.; Cases, E.; Saurel,R. Carbohyd. Polym. 2010, 80 (3), 820.
(27) Tømmeraas, K.; Mellergaard, M.; Malle, B. M.; Skagerlind, P.Carbohyd. Polym. 2011, 85 (1), 178.
(28) Van deWetering, P.; Zuidam, N. J.; Van Steenbergen, M. J.; Vander Houwen, O. A. G. J.; Underberg,W. J. M.; Hennink,W. E.Macromolecules 1998, 31 (23), 8065.
(29) Wu, Y.; Guo, J.; Yang,W. L.;Wang, C. C.; Fu, S. K. Polymer2006, 47 (15), 5289.
(30) Zhao, Y. Q.; Fei, F.; Yi, C. L.; Jiang, J. Q.; Luo, J.; Liu, X. Y.Acta Phys. -Chim. Sin. 2010, 26 (12), 3233. [赵艳琼, 费凡,易成林, 江金强, 罗静, 刘晓亚. 物理化学学报, 2010, 26
(12), 3233.] doi: 10.3866/PKU.WHXB20101217
(31) Cowman, M. K.; Matsuoka, S. Carbohyd. Res. 2005, 340 (5),805.
(32) Akiyama, E.; Kashimoto, A.; Fukuda, K.; Hotta, H.; Suzuki, T.;Kitsuki, T. J. Colloid Interface Sci. 2005, 282 (2), 452.
(33) Zinoviadou, K. G.; Scholten, E.; Moschakis, T.; Biliaderis, C. G.Int. Dairy J. 2012, 26 (1), 98.
(34) Amalvy, J. I.; Armes, S. P.; Binks, B. P.; Rodrigues, J. A.; Unali,G. F. Chem. Commun. 2003, 1827.
(35) Yi, C. L.; Yang, Y. Q.; Zhu, Y.; Liu, N.; Liu, X. Y.; Lou, J.;Jiang, M. Langmuir 2012, 28 (25), 9218.

[1]	Guoyong Xue, Jing Li, Junchao Chen, Daiqian Chen, Chenji Hu, Lingfei Tang, Bowen Chen, Ruowei Yi, Yanbin Shen, Liwei Chen. A Single-Ion Polymer Superionic Conductor [J]. Acta Phys. -Chim. Sin., 2023, 39(8): 2205012-0.
[2]	Qu Zhuoyan, Zhang Xiaoyin, Xiao Ru, Sun Zhenhua, Li Feng. Application of Organosulfur Compounds in Lithium-Sulfur Batteries [J]. Acta Phys. -Chim. Sin., 2023, 39(8): 2301019-0.
[3]	Ganyin Yuan, Zheng Xi, Chu Wang, Xiaohuan Sun, Jie Han, Rong Guo. Construction of Supramolecular Chiral Polyaniline-Gold Nanocomposite as Nanozyme for Enantioselective Catalysis [J]. Acta Phys. -Chim. Sin., 2023, 39(7): 2212061-0.
[4]	Youwen Rong, Jiaqi Sang, Li Che, Dunfeng Gao, Guoxiong Wang. Designing Electrolytes for Aqueous Electrocatalytic CO₂ Reduction [J]. Acta Phys. -Chim. Sin., 2023, 39(5): 2212027-0.
[5]	Jingwen Zhang, Hualong Ma, Jun Ma, Meixue Hu, Qihao Li, Sheng Chen, Tianshu Ning, Chuangxin Ge, Xi Liu, Li Xiao, Lin Zhuang, Yixiao Zhang, Liwei Chen. Cone Shaped Surface Array Structure on an Alkaline Polymer Electrolyte Membrane Improves Fuel Cell Performance [J]. Acta Phys. -Chim. Sin., 2023, 39(2): 2111037-0.
[6]	Yao Xie, Qitao Zhang, Hongli Sun, Zhenyuan Teng, Chenliang Su. Semiconducting Polymers for Photosynthesis of H₂O₂: Spatial Separation and Synergistic Utilization of Photoredox Centers [J]. Acta Phys. -Chim. Sin., 2023, 39(11): 2301001-.
[7]	Wenqian He, Ya Di, Nan Jiang, Zunfeng Liu, Yongsheng Chen. Graphene-Oxide Seeds Nucleate Strong and Tough Hydrogel-Based Artificial Spider Silk [J]. Acta Phys. -Chim. Sin., 2022, 38(9): 2204059-.
[8]	Hang Zhou, Kun Jiao. Carbonene Materials Modified High-Performance Polymer Fibers: Preparation, Properties, and Applications [J]. Acta Phys. -Chim. Sin., 2022, 38(9): 2111041-.
[9]	Shuai Chen, Jianglei Qin, Jianzhong Du. Cross-Linkable Yet Biodegradable Polymer Films [J]. Acta Phys. -Chim. Sin., 2022, 38(8): 2006029-.
[10]	Gaowei Han, Feiyan Xu, Bei Cheng, Youji Li, Jiaguo Yu, Liuyang Zhang. Enhanced Photocatalytic H₂O₂ Production over Inverse Opal ZnO@Polydopamine S-Scheme Heterojunctions [J]. Acta Phys. -Chim. Sin., 2022, 38(7): 2112037-.
[11]	Nanxiang Zhang, Zhuangzhuang Wei, Tao Feng, Feng Wu, Teng Zhao, Renjie Chen. Voltage-Sensitive Polytriphenylamine-Modified Separator for Over-Charge Protection in Li-S Batteries [J]. Acta Phys. -Chim. Sin., 2022, 38(6): 2107009-.
[12]	Xinrun Yu, Jun Ma, Chunbo Mou, Guanglei Cui. Percolation Structure Design of Organic-inorganic Composite Electrolyte with High Lithium-Ion Conductivity [J]. Acta Phys. -Chim. Sin., 2022, 38(3): 1912061-.
[13]	Ye Fan, Chongmei Cao, Yun Fang, Yongmei Xia. Fabrication of Fluorescent Nanodots by Self-Crosslinking Ufasomes of Conjugated Linoleic Acid and Their Unique Fluorescence Properties [J]. Acta Phys. -Chim. Sin., 2022, 38(3): 2002032-.
[14]	Xueling Lang, Shutao Lei, Bolong Li, Xiaohong Li, Bing Ma, Chen Zhao. Approaches for the Synthesis of High-Melting Waxes: A Review [J]. Acta Phys. -Chim. Sin., 2022, 38(10): 2204045-.
[15]	Hongsa Han, Yanqing Wang, Yunlong Zhang, Yuanyuan Cong, Jiaqi Qin, Rui Gao, Chunxiao Chai, Yujiang Song. Oxygen Reduction Reaction Electrocatalysts Derived from Metalloporphyrin-Modified Meso-/Macroporous Polyaniline [J]. Acta Phys. -Chim. Sin., 2021, 37(9): 2008017-.

Self-Assembled HA/PDM Particles and Emulsification Properties

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 0