水介质中药物-AOT混合物的温度依赖的混合胶束化行为

doi:10.3866/PKU.WHXB201402112

Abstract

Abstract:

The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride (AMT) in the presence of the conventional anionic surfactant sodium bis(2-ethylhexyl) sulfosuccinate (AOT) was studied at five different temperatures and compositions by the conductometric technique. The critical micelle concentration (cmc) and critical micelle concentration at the ideal state (cmc^id) values show mixed micelle formation between the components (i.e., drug and AOT). The micellar mole fractions of the AOT (X₁) values calculated using the Rubingh, Motomura, and Rodenas models show a higher contribution of AOT in the mixed micelles. The interaction parameter (β) is negative at all temperatures and the compositions show attractive interactions between the components. The activity coefficients (f₁ and f₂) calculated using the different proposed models are always less than unity indicating non-ideality in the systems. The ΔG_m^θ values were found to be negative for all the binary mixed systems. However, ΔH_m^θ values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures (293.15-303.15 K) and positive at higher temperatures (308.15 K and above). The ΔS_m^θ values are positive at all temperatures but their magnitude was higher at T=308.15 K and above. The excess free energy of mixing (ΔG_ex) determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug (AMT) and surfactant micelles.

Key words: Antidepressant drug, Amitriptyline hydrochloride, cmc, Interaction parameter, Thermodynamic parameters

RUB Malik Abdul, ASIRI Abdullah M, KUMAR Dileep, AZUM Naved, KHAN Farah. Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium[J].Acta Phys. -Chim. Sin., 2014, 30(4): 699-707.

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Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium

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