Acta Phys. -Chim. Sin. ›› 2014, Vol. 30 ›› Issue (7): 1363-1369.doi: 10.3866/PKU.WHXB201405063

• BIOPHYSICAL CHEMISTRY • Previous Articles     Next Articles

Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy

WANG Xin-Huan1,2, HAN Qiu-Sen2, LI Jing-Ying2, YANG Rong2, DIAO Guo-Wang1, WANG Chen2   

  1. 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China;
    2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • Received:2014-03-17 Revised:2014-05-06 Published:2014-06-30
  • Contact: YANG Rong, DIAO Guo-Wang, WANG Chen;;
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21261130090, 21073047) and Special Fund for Pilot Technology of Chinese Academy of Sciences (XDA09030303).


We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammoniumbromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cell growth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.

Key words: Gold nanorod, Plasmon resonance absorption, Biocompatibility, Surface functionalization, Hyperthermia