PEO-PPO嵌段聚醚的聚集行为及其在药物载体领域的应用

doi:10.3866/PKU.WHXB201603071

Abstract

Abstract:

Poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block polyethers are typical nonionic polymeric surfactants, which allow for wide structural design, exhibit temperature-dependent micellization of the copolymers, and function in a variety of solvent systems. It greatly enriched the investigation of their aggregation behaviors in various solutions. In this paper, an overview based on our research work was provided about the basic properties of linear and branched PEO-PPO block polyethers in aqueous solutions. Furthermore, the effects of additives including acid/base, inorganic salts, alcohols, surfactants and polymers on the aggregation behaviors of PEO-PPO polyethers are examined. PEO-PPO block polyethers have good biocompatibility. They can form micelles in aqueous solutions, with a hydrophobic core and a hydrophilic corona around the micelle interior. This micelle structure provides local hydrophobic microenvironments for hydrophobic drugs. Thus, the application of PEO-PPO polyethers in the field of drug delivery is presented; they can be the theoretical dosage support structure in future drug discovery research.

Key words: Pluronic, Tetronic, Branched block polyether, Aggregation behavior, Drug carrier

Teng LIU,Hai-Yang WANG,Gui-Ying XU. Aggregation Behavior of PEO-PPO Block Polyethers and Their Application as a Drug Carrier[J]. Acta Phys. -Chim. Sin. 2016, 32(5), 1072-1086. doi: 10.3866/PKU.WHXB201603071

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Aggregation Behavior of PEO-PPO Block Polyethers and Their Application as a Drug Carrier

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