铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗

doi:10.1016/j.actphy.2025.100046

Abstract

Abstract:

The pressing challenges posed by infectious diseases caused by pathogenic microbial infections have necessitated the development of advanced antimicrobial strategies. Among the promising avenues, photodynamic therapy (PDT) has emerged as a promising approach due to its non-invasive and targeted nature. Although it has been widely used in antibacterial therapy, there are still obstacles in precisely regulating the structure of photosensitizers to achieve satisfactory photodynamic performance. Herein, Pt single-atoms (SAs) are deposited on two-dimensional (2D) Al-TCPP metal-organic framework (MOF) nanosheets, creating Pt/Al-TCPP as the photosensitizer to boost reactive oxygen species (ROS) production for enhanced photodynamic antimicrobial therapy. By integrating Pt SAs onto 2D Al-TCPP MOF nanosheets, we not only improve the dispersion and stability of Pt atoms but also harness the synergistic effect between the MOF's crystal porous structure and Pt SAs, optimizing its light-trapping ability. This unique structure enhances the bridging unit between Pt SA and the porphyrin linker, facilitating efficient charge transfer and separation during illumination, ultimately boosting ROS production. In addition to the inherent photodynamic performance of Pt SAs, they can also increase the adsorption of oxygen, facilitate electron transfer, and improve charge separation, thus enhancing photodynamic ROS generation efficiency. Therefore, the Pt/Al-TCPP photosensitizer shows much greater efficacy in generating ROS under a 660 nm laser irradiation compared to Al-TCPP. Both in vitro and in vivo experiments demonstrate that the Pt/Al-TCPP nanosheets can effectively eliminate bacteria and promote wound healing in a short time at low doses under laser irradiation. This study underscores the advantages of integrating Pt SAs with Pt/Al-TCPP nanosheets and offers a highly effective photosensitizer for bacterial infections. The results pave the way for novel strategies in the antibacterial realm, highlighting the potential of Pt/Al-TCPP nanosheets as a promising therapeutic agent for efficient wound healing.

Key words: Pt single-atoms, 2D MOFs, Photodynamic therapy, Antimicrobial, Wound healing

Shiyang He, Dandan Chu, Zhixin Pang, Yuhang Du, Jiayi Wang, Yuhong Chen, Yumeng Su, Jianhua Qin, Xiangrong Pan, Zhan Zhou, Jingguo Li, Lufang Ma, Chaoliang Tan. Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy[J]. Acta Phys. -Chim. Sin. 2025, 41(5), 100046. doi: 10.1016/j.actphy.2025.100046

Figures/Tables 4

Fig 1

Fig 2

Fig 3

Fig 4

References 62

1	Lin H.; Yang C.; Luo Y.; Ge M.; Shen H.; Zhang X.; Shi J. ACS Nano 2022, 16, 5943. doi: 10.1021/acsnano.1c11132
2	Bian Y.; Zhao K.; Hu T.; Tan C.; Liang R.; Weng X. Adv. Sci. 2024, 11, 2403791. doi: 10.1002/advs.202403791
3	Hu T.; Gu Z.; Williams G.; Strimaite M.; Zha J.; Zhou Z.; Zhang X.; Tan C.; Liang R. Chem. Soc. Rev. 2022, 51, 6126. doi: 10.1039/d2cs00236a
4	Wang W.; Cui Y.; Wei X.; Zang Y.; Chen X.; Cheng L.; Wang X. ACS Nano 2024, 18, 15845. doi: 10.1021/acsnano.4c02825
5	Zhao X.; Qiu H.; Shao Y.; Wang P.; Yu S.; Li H.; Zhou Y.; Zhou Z.; Ma L.; Tan C. Acta Phys. -Chim. Sin. 2023, 39, 2211043.
	赵信硕; 邱海燕; 邵依; 王攀捷; 余石龙; 李海; 周郁斌; 周战; 马录芳; 谭超良. 物理化学学报, 2023, 39, 2211043. doi: 10.3866/PKU.WHXB202211043
6	Li X.; Zhao X.; Chu D.; Zhu X.; Xue B.; Chen H.; Zhou Z.; Li J. Surf. Interfaces 2022, 33, 102247. doi: 10.1016/j.surfin.2022.102247
7	Yang Y.; Liang H.; Tang C.; Cheng Y.; Cheng L. Adv. Funct. Mater. 2024, 34, 2313454. doi: 10.1002/adfm.202313454
8	Zhu D.; Lu Y.; Yang S.; Hu T.; Tan C.; Liang R.; Wang Y. Adv. Sci. 2024, 11, 2401064. doi: 10.1002/advs.202401064
9	Huang X.; Cheng S.; Yang X.; Pei Z.; Cui X.; Hou G.; Yang N.; Han Z.; Chen Y.; Cheng Y.; et al Nano Today 2024, 57, 102400. doi: 10.1016/j.nantod.2024.102400
10	Zhang Y.; Zhang N.; Xing J.; Sun Y.; Jin X.; Shen C.; Cheng L.; Wang Y.; Wang X. Biomaterials 2024, 311, 122675. doi: 10.1016/j.biomaterials.2024.122675
11	Hu T.; Zhou Z.; Zha J.; Williams G.; Wu Z.; Zhao W.; Shen W.; Li H.; Weng X.; Liang R.; et al Fundam. Res. 2024, 4, 926. doi: 10.1016/j.fmre.2022.06.001
12	Wei K.; Wu Y.; Zheng X.; Ouyang L.; Ma G.; Ji C.; Yin M. Angew. Chem. Int. Ed. 2024, 63, e202404395. doi: 10.1002/anie.202404395
13	Zhao X.; He X.; Hou A.; Cheng C.; Wang X.; Yue Y.; Pei C.; Liu B.; Li H.; Shen J.; et al Inorg. Chem. 2022, 61, 9328. doi: 10.1021/acs.inorgchem.2c01091
14	Hou A.; Du Y.; Su Y.; Pang Z.; Liu S.; Xian S.; Zhao X.; Ma L.; Liu B.; Wu H.; et al ACS Appl. Nano Mater. 2024, 7, 10998. doi: 10.1021/acsanm.4c02067
15	Dang L.; Zheng J.; Zhang J.; Chen T.; Chai Y.; Fu H.; Aznarez F.; Liu S.; Li D.; Ma L. Angew. Chem. Int. Ed. 2024, 63, e202406552. doi: 10.1002/anie.202406552
16	Zhou Z.; Li X.; Hu T.; Xue B.; Chen H.; Ma L.; Liang R.; Tan C. Adv. NanoBiomed Res. 2022, 2, 2200065. doi: 10.1002/anbr.202200065
17	Zhao Y.; Chai Y.; Chen T.; Zheng J.; Li T.; Aznarez F.; Dang L.; Ma L. Chin. Chem. Lett. 2024, 35, 109298. doi: 10.1016/j.cclet.2023.109298
18	Zhou Z.; Wang Y.; Peng F.; Meng F.; Zha J.; Ma L.; Du Y.; Peng N.; Ma L.; Zhang Q.; et al Angew. Chem. Int. Ed. 2022, 61, e202115939. doi: 10.1002/anie.202115939
19	Li B.; Chu D.; Cui H.; Li Z.; Zhou Z.; Tan C.; Li J. SmartMat 2023, 4, e1243. doi: 10.1002/smm2.1243
20	Shen W.; Hu T.; Liu X.; Zha J.; Meng F.; Wu Z.; Cui Z.; Yang Y.; Li H.; Zhang Q.; et al Nat. Commun. 2022, 13, 3384. doi: 10.1038/s41467-022-31106-9
21	Xue B.; Geng X.; Cui H.; Chen H.; Wu Z.; Chen H.; Li H.; Zhou Z.; Zhao M.; Tan C.; et al Chin. Chem. Lett. 2023, 34, 108140. doi: 10.1016/j.cclet.2023.108140
22	Xu D.; Lin H.; Qiu W.; Ge M.; Chen Z.; Wu C.; You Y.; Lu X.; Wei C.; Liu J.; et al Biomaterials 2021, 278, 121172. doi: 10.1016/j.biomaterials.2021.121172
23	Li Z.; Zhang J.; Tian X.; Yang S.; Chen S.; Zhou H.; Yang X. Chem. Sci. 2022, 13, 9381. doi: 10.1039/d2sc02662g
24	He L.; Brasino M.; Mao C.; Cho S.; Park W.; Goodwin A.; Cha J. Small 2017, 13, 1700504. doi: 10.1002/smll.201700504
25	Zhen W.; Kang D.; Fan Y.; Wang Z.; Germanas T.; Nash G.; Shen Q.; Leech R.; Li J.; Engel G.; et al J. Am. Chem. Soc. 2024, 146, 16609. doi: 10.1021/jacs.4c03519
26	Ma A.; Chen H.; Cui Y.; Luo Z.; Liang R.; Wu Z.; Chen Z.; Yin T.; Ni J.; Zheng M.; et al Small 2019, 15, 1804028. doi: 10.1002/smll.201804028
27	Lu X.; Zhang K.; Niu X.; Ren D.; Zhou Z.; Dang L.; Fu H.; Tan C.; Ma L.; Zang S. Chem. Soc. Rev. 2024, 53, 6694. doi: 10.1039/D3CS01026K
28	Zhao Y.; Wu D.; Qiao Y.; Yang G.; Ma L.; Wang Y. Inorg. Chem. Front. 2024, 11, 2071. doi: 10.1039/d3qi02527f
29	Yang X.; Zhang J.; Tian X.; Qin J.; Zhang X.; Ma L. Angew. Chem. Int. Ed. 2022, 61, e202216699. doi: 10.1002/anie.202216699
30	Gao P.; Zhang K.; Ren D.; Liu H.; Zhang H.; Fu H.; Ma L.; Li D. Adv. Funct. Mater. 2023, 33, 2300105. doi: 10.1002/adfm.202300105
31	Wu Q.; Li A.; He R.; Wu Y.; Hou L.; Yang G.; Zhang W.; Wang Y. Chin. Chem. Lett. 2024, 35, 108639. doi: 10.1016/j.cclet.2023.108639
32	Lai K.; Li F.; Li N.; Gao Y.; Ge L. Acta Phys. -Chim. Sin. 2024, 40, 2304018.
	赖可溱; 李丰彦; 李宁; 高旸钦; 戈磊. 物理化学学报, 2024, 40, 2304018. doi: 10.3866/PKU.WHXB202304018
33	Qin J.; Xiao Z.; Xu P.; Li Z.; Lu X.; Yang X.; Lu W.; Ma L.; Li D. Inorg. Chem. 2022, 61, 13234. doi: 10.1021/acs.inorgchem.2c01517
34	Li J.; Song S.; Meng J.; Tan L.; Liu X.; Zheng Y.; Li Z.; Yeung K.; Cui Z.; Liang Y.; et al J. Am. Chem. Soc. 2021, 143, 15427. doi: 10.1021/jacs.1c07875
35	Tang Q.; Feng L.; Li Z.; Wu S.; Zhang L.; Sun Q.; Wu M.; Zou J. Chin. Chem. Lett. 2024, 35, 109454. doi: 10.1016/j.cclet.2023.109454
36	He W.; Hu J.; Cui Y.; Li J.; Si Y.; Wang S.; Zhao Y.; Zhou Z.; Ma L.; Zang S. Natl. Sci. Rev. 2024, 11, nwae174. doi: 10.1093/nsr/nwae174
37	Zhu R.; Kang L.; Li L.; Pan X.; Wang H.; Su Y.; Li G.; Cheng H.; Li R.; Liu X.; et al Acta Phys. -Chim. Sin. 2024, 40, 2303003.
	朱锐杰; 康磊磊; 李林; 潘晓丽; 王华; 苏杨; 李广亿; 程鸿魁; 李仁贵; 刘晓艳; 等. 物理化学学报, 2024, 40, 2303003. doi: 10.3866/PKU.WHXB202303003
38	He W.; Zhou Z.; Han Z.; Li S.; Zhou Z.; Ma L.; Zang S. Angew. Chem. Int. Ed. 2021, 60, 8505. doi: 10.1002/anie.202100006
39	Wang X.; Kang Z.; Wang D.; Zhao Y.; Xiang X.; Shang H.; Zhang B. Nano Energy 2024, 121, 109268. doi: 10.1016/j.nanoen.2024.109268
40	Wang B.; Chen S.; Zhang Z.; Wang D. SmartMat 2022, 3, 84. doi: 10.1002/smm2.1101
41	Kim J.; Wu S.; Zdrazil L.; Denisov N.; Schmuki P. Angew. Chem. Int. Ed. 2024, 63, e202319255. doi: 10.1002/anie.202319255
42	Yao S.; Zhang X.; Zhou W.; Gao R.; Xu W.; Ye Y.; Lin L.; Wen X.; Liu P.; Chen B. Science 2017, 357, 389. doi: 10.1126/science.aah4321
43	Chang J.; Hülsey M.; Wang S.; Li M.; Ma X.; Yan N. Angew. Chem. Int. Ed. 2023, 62, e202218265. doi: 10.1002/anie.202218265
44	Zhou J.; Xu D.; Tian G.; He Q.; Zhang X.; Liao J.; Mei L.; Chen L.; Gao L.; Zhao L.; et al J. Am. Chem. Soc. 2023, 145, 4279. doi: 10.1021/jacs.2c13597
45	Le X.; Nguyen N.; Lee W.; Yang Y.; Choi H.; Youn Y. Adv. Funct. Mater 2024, 34, 2401893. doi: 10.1002/adfm.202401893
46	Feng G.; Huang H.; Zhang M.; Wu Z.; Sun D.; Chen Q.; Yang D.; Zheng Y.; Chen Y.; Jing X. Adv. Sci. 2023, 10, 2302579. doi: 10.1002/advs.202302579
47	Yin Y.; Ge X.; Ouyang J.; Na N. Nat. Commun. 2024, 15, 2954. doi: 10.1038/s41467-024-46987-1
48	Wang L.; Qu X.; Zhao Y.; Weng Y.; Waterhouse G.; Yan H.; Guan S.; Zhou S. ACS Appl. Mater. Interfaces 2019, 11, 35228. doi: 10.1021/acsami.9b11238
49	Feng X.; Lei J.; Ma L.; Ouyang Q.; Zeng Y.; Liang H.; Lei C.; Li G.; Tan L.; Liu X.; et al Small 2022, 18, 2105775. doi: 10.1002/smll.202105775
50	Wang D.; Wang J.; Gao X.; Ding H.; Yang M.; He Z.; Xie J.; Zhang Z.; Huang H.; Nie G.; et al Adv. Mater. 2024, 36, 2310033. doi: 10.1002/adma.202310033
51	Zhou Z.; Wang T.; Hu T.; Xu H.; Cui L.; Xue B.; Zhao X.; Pan X.; Yu S.; Li H.; et al Adv. Mater. 2024, 36, 2311002. doi: 10.1002/adma.202311002
52	Zhou Z.; Wang T.; Hu T.; Cheng C.; Yu S.; Li H.; Liu S.; Ma L.; Zhao M.; Liang R.; et al Mater. Chem. Front. 2023, 7, 1684. doi: 10.1039/d2qm01333a
53	Fateeva A.; Chater P.; Ireland C.; Tahir A.; Khimyak Y.; Wiper P.; Darwent J.; Rosseinsky M. Angew. Chem. Int. Ed. 2012, 51, 7440. doi: 10.1002/anie.201202471
54	Fang X.; Shang Q.; Wang Y.; Jiao L.; Yao T.; Li Y.; Zhang Q.; Luo Y.; Jiang H. Adv. Mater. 2018, 30, 1705112. doi: 10.1002/adma.201705112
55	Oshida K.; Yuan K.; Yamazaki Y.; Tsukimura R.; Nishio H.; Nomoto K.; Miura H.; Shishido T.; Jin X.; Nozaki K. Angew. Chem. Int. Ed. 2024, 63, e202403092. doi: 10.1002/anie.202403092
56	Zhang S.; Li Y.; Ding C.; Niu Y.; Zhang Y.; Yang B.; Li G.; Wang J.; Ma Z.; Yu L. Small Struct. 2023, 4, 2200115. doi: 10.1002/sstr.202200115
57	Xu T.; Zhao H.; Zheng H.; Zhang P. Chem. Eng. J. 2020, 385, 123832. doi: 10.1016/j.cej.2019.123832
58	Jin L.; Yan S.; Du M.; Zhang J.; Wu N.; Liu G.; Chen H.; Yuan C.; Qin A.; Liu X. J. Colloid Interface Sci. 2024, 662, 183. doi: 10.1016/j.jcis.2024.02.049
59	Xu T.; Zheng H.; Zhang P. J. Hazard. Mater. 2020, 388, 121746. doi: 10.1016/j.jhazmat.2019.121746
60	Guan G.; Zheng S.; Xia M.; Li K.; Ouyang Y.; Yang G.; Yang Q. Chem. Eng. J. 2023, 464, 142530. doi: 10.1016/j.cej.2023.142530
61	Zhou R.; Lv W.; Li B.; Yu B.; Zhang S.; Zhou Y.; Liu S.; Zhao Q. Sci. China Chem. 2024, 67, 604. doi: 10.1007/s11426-023-1836-y
62	Chen Y.; Wang Z.; Wang H.; Lu J.; Yu S.; Jiang H. J. Am. Chem. Soc. 2017, 139, 2035. doi: 10.1021/jacs.6b12074

[1]	Xinshuo Zhao, Haiyan Qiu, Yi Shao, Panjie Wang, Shilong Yu, Hai Li, Yubin Zhou, Zhan Zhou, Lufang Ma, Chaoliang Tan. Silver Nanoparticle-Modified 2D MOF Nanosheets for Photothermally Enhanced Silver Ion Release Antibacterial Treatment [J]. Acta Phys. -Chim. Sin., 2023, 39(7): 2211043-0.
[2]	Chiaki TOMINAGA,Dailo HIKOSOU,Issey OSAKA,Hideya KAWASAK. Ag₇(MBISA)₆ Nanoclusters Conjugated with Quinacrine for FRET-Enhanced Photodynamic Activity under Visible Light Irradiation [J]. Acta Phys. -Chim. Sin., 2018, 34(7): 805-811.
[3]	Jian-Xia HUO,Su-Wei SONG,Cheng-Wei JIN,Ning REN,Li-Na GENG,Jian-Jun ZHANG. Synthesis, Characterization, Thermal Decomposition Mechanism and Properties of the [Eu(4-MOBA)₃(terpy)(H₂O)]₂ Complex [J]. Acta Phys. -Chim. Sin., 2016, 32(4): 901-906.
[4]	Huang Jian-Dong,Liu Er-Sheng,Yang Su-Ling,Ouyang Rui-Zhen,Chen Nai-Sheng,Huang J. The Ability of Photosensitization and Anti-cancer of ZnPcSP under Different Exciting Wavelength [J]. Acta Phys. -Chim. Sin., 1997, 13(03): 247-251.

Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy

RichHTML

Full text @ ScienceDirect

Like

Supplement

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 4

References 62

Related Articles 4

Metrics

Recommended 0